PhD candidate 'Advanced analysis of total knee arthroplasty mechanics'

PhD candidate 'Advanced analysis of total knee arthroplasty mechanics'

Published Deadline Location
22 Sep 2 Nov Nijmegen

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Job description

Total knee arthroplasty is an intervention to treat osteoarthritis. During surgery the damaged cartilage surfaces of the femur and tibia are replaced by implants that together form the new articulating surface of the knee joint. The procedure is quite popular (+20.000 surgeries every year in the Netherlands), has an impressive survival rate, and provides immediate pain relief for patients. We are looking for a motivated and talented PhD candidate to participate in a new project that investigates the primary fixation of PEEK cementless total knee arthroplasty components.

Within this project you will collaborate with Invibio Ltd, an orthopaedic company that develops novel orthopaedic implants. Together with Invibio, we are investigating the use of the advanced material polyether ether ketone (PEEK) for total knee arthroplasty. PEEK is a high-quality material that is already being used in several orthopaedic applications, such as fracture plates and spinal cages. A notable difference with other materials currently being used is it significantly lower stiffness.

Within the project you will investigate how this influences the primary and long-term fixation of the implant. For this purpose, you use computational modelling based on finite element analysis. You will develop and apply advanced simulations to simulate the osseointegration process of cementless implants. You will use population-based analyses to investigate the effects of variability in factors related to the patient, surgery, and implant, and define the optimal parameters for total knee reconstructions.

Tasks and responsibilities
  • Develop and perform scientific research in the field of orthopaedics, biomechanics, and image processing.
  • Generate and analyze data, write scientific publications, and present findings at scientific meetings.
  • Participate in educational activities of the department.
  • Work in an international and multidisciplinary team of scientists to discuss, plans and perform research in a stimulating environment.
  • Complete the research project with a scientific dissertation.


Radboud University Medical Center (Radboudumc)


We are looking for someone with a master's degree in biomedical or (bio) mechanical engineering, biomedical sciences, technical medicine, or a closely related discipline. You have experience in or affinity with finite element modelling and you have a strong motivation to succeed in scientific research.
You are independent and have a well-structured working style. Lastly you have well-developed social skills directed to work in a team.

Conditions of employment

Fixed-term contract: 4 years.

Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. And there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At Radboud university medical center, you will be given trust, and you will take the responsibility to handle everything together. We provide annual courses, both professional and personal.
  • A gross monthly salary between € 2.789 and € 3.536 (scale 10A) based on full-time employment.
  • From 1 November 2023 the wages will increase by 4%.
  • An annual vacation allowance of 8% and an end-of-year bonus of 8.3%.
  • If you work irregular hours, you will receive an allowance.
  • As a full-time employee (36 hours per week), you are entitled to approximately 168 vacation hours (over 23 days) per year.
  • Radboud university medical center pays 70% of the pension premium. You pay the rest of the premium with your gross salary.
  • Discount on your supplementary health insurance. You can make use of two collective health insurance policies: UMC Health Insurance and CZ Collective. They offer many extras to stay vital and healthy, such as a prevention budget, workshops, and apps.

In addition to our terms of employment, we also offer employees various other attractive facilities, such as childcare and sports facilities. Want to learn more? Take a look at the Cao UMC.



The Orthopaedic Research Lab (ORL) of the Radboudumc performs fundamental and applied research in the field of orthopaedics. Our multidisciplinary team consists of engineers, biomedical scientists, physicians, and technical physicians. The goal of orthopaedic surgery is to reconstruct deformities and defects of the musculoskeletal system. Our research focuses on the external loads applied to the musculoskeletal system, and how these loads influence the reconstructions.

Welcome to Radboud university medical center (Radboudumc), where scientific breakthroughs are born through the curiosity and passion of our collaborating researchers in a vibrant environment. We believe trust and excitement are crucial elements to achieving our goals, and we approach our research as teams and with the utmost rigor to make a significant impact on health and healthcare. Our researchers are driven by their fascination with the biological, psychological, and sociological mechanisms underlying health and healthcare. They collaborate with partners from all over the world to improve health outcomes for all. Radboudumc unites patient care, research, education, and corporate learning, which allows us to approach our mission to shape the health and healthcare of the future in an innovative and person-centered way.

Our ambition is to lead the way in the pursuit of prevention, sustainability, meaningful care. We believe that through our research, we can significantly improve the health and well-being of society. Join us on our mission to make a difference in healthcare. Become a part of our community of gifted researchers, professionals or patient partners who are dedicated to making a real impact on population health and healthcare.

Read what it is like to do a PhD at the Radboud University Medical Center.

Read more about working at Radboud university medical center means.


  • PhD
  • Natural sciences; Health
  • max. 36 hours per week
  • €2789—€3536 per month
  • University graduate
  • 188240-P1325693-1


Radboud University Medical Center (Radboudumc)

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Geert Grooteplein-Zuid 10, 6525 GA, Nijmegen

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