PhD candidate for Exposomics approaches to understand the impact of environment on health

PhD candidate for Exposomics approaches to understand the impact of environment on health

Published Deadline Location
31 Oct today Leiden
The Metabolomics & Analytics Centre (MAC) at the Leiden Academic Centre for Drug Research (LACDR) at Leiden University is looking for a:

PhD candidate for Exposomics approaches to understand the impact of environment on health
Vacancy number:14243

Job description

Project description
MAC seeks to hire a PhD student for the development of an innovative GC-Orbitrap MS method to study the impact of environmental factors on health and disease. You will address the identification of possible hazardous chemicals to which citizens and workers are exposed, and you will predict computationally or experimentally which metabolites you may detect for possible hazardous chemicals. You will increase the sensitivity of the exposomics method using an innovative and automated robotic sample preparation including the use of a hanging droplet evaporator that allows the evaporation of the sample from e.g. 20 microlitre or more to less than one microlitre prior to injection into the GC. You will focus on the identification of the small molecules you detect. You will integrate the data from possible hazardous chemicals with other environmental factors such as diet and lifestyle, and will try to link them with host response markers suggesting physiological perturbations. You will work together with researchers at Utrecht University, ArboUnie and within the Exposome-NL consortium to evaluate the collected data and to predict possible health risks by correlating your data with other health parameters.

Key responsibilities
  • Focus on 1) developing an innovative GC-Orbitrap MS method to study the exposome, including automation of the sample preparation and data handling, 2) identify novel or known hazardous chemicals, and 3) develop strategies how to evaluate the possible risks to citizens and workers based on the collected exposomics data, including host response markers suggesting physiological perturbations.
  • Support education activities in the bachelor and master programs of analytical biosciences.
  • Publish scientific articles in international peer-review journals, present at national and international conferences and follow PhD courses based on individual training and supervision plan.

Specifications

Leiden University

Requirements

Selection criteria
  • Recent master’s degree in Chemistry/Biochemistry, Biopharmaceutical Sciences, Life Sciences, Biomedical Sciences, or comparable, preferably with a major in Analytical Chemistry
  • Interest in the field of metabolomics/exposomics, automation, physiology & systems biology, bioinformatics
  • Independent and creative team player with strong communication skills
  • Proficient in spoken and written English
  • Excellent organisational and planning skills (efficient time management)

Conditions of employment

Terms and conditions
We offer a full-time appointment initially for one year. After a positive evaluation of the progress of the research, teaching evaluations, personal capabilities and compatibility, the appointment will be extended for another three years. You will be appointed in accordance with the Collective Labour Agreement for Dutch Universities. The salary ranges from € 2.770,- per month in the first year to € 3.539,- gross per month in the fourth year based on a full-time position (pay scale P).

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %), training and career development. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. For international spouses we have set up a dual career program. Candidates from outside the Netherlands may be eligible for a substantial tax break. For more information, see the website: https://www.universiteitleiden.nl/en/working-at/job-application-procedure-and-employment-conditions.

All our PhD students are embedded in the Leiden University Graduate School of Science. Our graduate school offers several PhD training courses at three levels: professional courses, skills training and personal effectiveness. In addition, advanced courses to deepen scientific knowledge are offered by the research school.

Diversity and work-life balance
Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups. LACDR is a highly diverse institute, in culture, background, and gender. We stand for excellence in a caring Institute. We wish to reflect society in all aspects, as we believe that this improves the dynamics in our organization. Therefore, we support and understand the need for a work/life/family balance and consequent varying working hours and places. We believe that doing good science is fun, and goes hand in hand with a friendly culture.

Employer

Universiteit Leiden

Our organization
Working at the Faculty of Science means being part of an exciting, dynamic scientific environment which sets high standards for its students and staff. The research carried out at the Faculty of Science is diverse, ranging from computer science, mathematics, astronomy, physics, chemistry and bio-pharmaceutical sciences to biology and environmental sciences.

The faculty has grown strongly in recent years and now has more than 2,300 staff and over 5,000 students. We are located at the heart of Leiden's Bio Science Park, one of Europe's biggest science parks, where university and business life come together. For more information, see https://www.universiteitleiden.nl/en/science.

MAC has been a pioneer in metabolomics since early 2000, and combines advanced metabolomics technologies, innovative sample preparation and robotics for high throughput analysis of clinical samples, organ-on-a-chip models, and computational and FAIR digital twinning expertise. MAC houses a beyond-state-of-the-art metabolomics and mass spectrometry lab with automated and robotic sample preparation. Patient-derived in-vitro and organ-on-chip models are used to understand the effect of hazardous chemicals and early metabolic markers of diseases, and MAC has access to state-of-the-art in-vitro models and advanced imaging facilities. MAC is involved in many national and international academic, clinical and industrial collaborations, and has the ambition to translate findings and technologies into healthcare and drug research.

Additional information

Information
Enquiries can be made to Prof. dr. Thomas Hankemeier (hankemeier@lacdr.leidenuniv.nl). If you have any questions about the procedure, please contact Mrs. Ina Hazejager (s.a.hazejager@lacdr.leidenuniv.nl)

Specifications

  • PhD
  • Natural sciences
  • €2770—€3539 per month
  • University graduate
  • 14243

Employer

Location

Leiden, 2312TT, Leiden

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Application procedure

Instructions for applications
To apply for this vacancy, please press on the blue button below. Please ensure that you include the following additional documents quoting the vacancy number:
  • Motivation letter;
  • Full curriculum vitae;
  • A list of grades;
  • Two references.

Only applications received before 30 November 2023 can be considered.

Application procedure

Application procedure

Instructions for applications
To apply for this vacancy, please press on the blue button below. Please ensure that you include the following additional documents quoting the vacancy number:
  • Motivation letter;
  • Full curriculum vitae;
  • A list of grades;
  • Two references.

Only applications received before 30 November 2023 can be considered.

Make sure to apply no later than 30 Nov 2023 23:59 (Europe/Amsterdam).