Mass spectrometry imaging (MSI) is an exciting technique that is gaining popularity in the fields of biomedicine and medical diagnostics for its ability to chemically image tissues without the use of labels . MSI produces images of the locations of biochemical compounds that can help us understand and even better diagnose diseases such as cancer. Along with the rapid growth of computer and imaging systems capable of performing ever more complicated imaging experiments, MSI has recently had several instrumental and methodological advancements that enable it to achieve higher spatial resolution , higher molecular information , and faster throughput  than ever before.
This PhD project aims to develop new MSI instrumentation and corresponding methods to push the boundaries of MSI information content, spatial resolution, and throughput. Multimodal forms of analysis, such as combining MSI with fluorescence microscopy and/or electron microscopy will be an important part of this PhD project. The context for the research is to produce insights, methods, and technologies using multimodal MSI to yield better biomedical information.
Along the way, many of the skills you will develop and use will include electrical engineering, ion and chemical flight modeling, use of advanced imaging technologies and software, analytical and imaging methodologies, programming (both control and data processing software), and chemometrics. Furthermore, you are expected to present your work in scientific journals and at scientific conferences which will utilize skills such as technical writing, public speaking, and study of the current scientific literature base. You will also be able to gain experience teaching and mentoring bachelor and master students.
The PhD position will be supervised by Dr. Ian Anthony and Prof. Ron Heeren. The position is a 4-year long (full-time) paid position at Maastricht University in Maastricht, Netherlands. The anticipated start date is Early Spring 2024, but reasonable accommodations can be made for the right candidate.
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