On the one hand, antibiotic resistance remains a growing issue in modern society, propagated in part by the misuse of antibiotics. On the other hand, bacterial infections have caused millions of deaths and remain a major healthcare challenge. Rising antibiotic resistance, driven by misuse and a lack of new antibiotics, threatens a post-antibiotic era. The Microsystems section (TU Eindhoven), the Catharina Hospital and ShanX Medtech BV (SXM, NL) are developing and validating a chemical-based novel diagnostic tool to help doctors prescribe optimal and personalized antibiotic treatments to reduce antibiotic misuse. This project will focus on the expansion and optimization of the chemical assay, giving you the opportunity to make a significant impact on patient treatment and outcomes.

This post-doc position focusses on the development of the chemical assay found within the microwells of the SXM test cartridges. Armed with a multi-disciplinary background - that combines knowledge of microbiology, bacterial processes, basic chemistry, microfluidics, and data science - you will explore methods by which the current assay can be improved, expanded, and utilized for novel purposes. Herein, you will design novel assay compositions, generate an experimental proof-of-principle therewith, and determine its overall performance through data analysis.

Embedding

The postdoc researcher will be embedded in the Microsystems research section at the Department of Mechanical Engineering, headed by prof.dr.ir. Jaap den Toonder, with frequent commuting to ShanX Medtech premises.

We seek a motivated researcher with a PhD and a core background in either Chemical Biology, Microbiology, or closely related subject. Requirements:

• Demonstratable knowledge of metabolic processes and/or metabolite detection is preferred.
• Proficiency in chemical principles and fluorescence measurements.
• The ability to develop mathematical models and analyze large data sets, preferably with experience using machine learning or artificial intelligence based models is preferred
• Capacity to work in a multidisciplinary group, communicating both with university colleagues and liaisons from SXM
• Proficiency in English (spoken and written), strong project management skills, including the ability to complete tasks on schedule, and a proactive, independent work ethic.

We offer a meaningful job in a dynamic and ambitious university, in an interdisciplinary setting and within an international network. You will work on a beautiful, green campus within walking distance of the central train station. In addition, we offer you:

• An exciting job in a dynamic work environment and a multidisciplinary consortium.
• A full time appointment for 2 years by Eindhoven University of Technology (www.tue.nl/en), with an anticipated start date 1 February 2025.
• A gross monthly salary between €4,020 and €5,278 (on a full-time basis), based on knowledge and experience, in accordance with the Collective Labour Agreement for Dutch Universities.
• A year-end bonus of 8.3% and annual vacation pay of 8%.
• High-quality training programs on general skills, didactics and topics related to research and valorization.
• An excellent technical infrastructure, on-campus children's day care and sports facilities.
• Partially paid parental leave and an allowance for commuting, working from home and internet costs.
• A TU/e Postdoc Association that helps you to build a stronger and broader academic and personal network, and offers tailored support, training and workshops.
• A Staff Immigration Team is available for international candidates, as are a tax compensation scheme (the 30% facility) and a compensation for moving expenses.

About TU/e

Eindhoven University of Technology (TU/e) is an internationally top-ranking university in the Netherlands that combines scientific curiosity with a hands-on attitude. Our spirit of collaboration translates into an open culture and a top-five position in collaborating with advanced industries. Fundamental knowledge enables us to design solutions for the highly complex problems of today and tomorrow. 

Information

Do you recognize yourself in this profile and would you like to know more? To learn more about the project, please contact prof. Jaap den Toonder (j.m.j.d.toonder@tue.nl) .

Visit our website for more information about the application process or the conditions of employment. For questions about the application process, you can also contact Hind Boulgalag, HR Advisor, at h.boulgalag@tue.nl,  or +31 40 247 5902.

Are you inspired and would like to know more about working at TU/e? Please visit our career page.

Application

We invite you to submit a complete application by using the apply button. The application should include:

• A cover letter in which you describe your motivation and qualifications for this specific position.
• A Curriculum vitae, including a list of your publications/patents/achievements and the contact information of at least two references.
• A copy of your PhD diploma and thesis.

We look forward to receiving your application and will screen it as soon as possible. The vacancy will remain open until the position is filled.