You will conduct research into the genetic background of atypical femur fractures (AFFs) associated with the use of antiresorptive drugs. These unusual fractures are a very rare but serious side effect of bisphosphonates and other inhibitors of bone resorption that are used to prevent fractures in patients with osteoporosis. Despite the fact that the chance of an AFF is very small, the fear of such a side effect, both among doctors and patients, has resulted in a large decline of about 50% in the use of these effective anti-fracture drugs, leading to under-treatment of patients with osteoporosis. It is likely that patients with AFF have a genetic predisposition with specific genetic variants and an altered gene expression profile. These variants may interact with non-genetic factors like use of certain medication and clinical characteristics.

We aim to unravel these characteristics with the ultimate objective to develop a cheap genetic test in order to predict the occurrence of AFFs and restore faith in the use of bisphosphonates. In our Bone Center, an expert center for rare and complex bone diseases, we see most patients from the Netherlands with an AFF. We also collaborate with international consortia to build a large cohort of AFF cases. In our lab, we use 'state of the art' genomic and proteomic analyses.

The candidate holds a MSc Degree in Medicine or Life Sciences (Biomedical Sciences, Medical Informatics, Bioinformatics, Health Sciences, Biology or Biochemistry or equivalent) with a strong interest in clinical and genetic research. We seek a talented and ambitious researcher who is flexible and has good communicative skills with a high proficiancy in both spoken and written English. The candidate preferably has experience in - or is interested in learning - modern data processing and statistical programs. We offer the possibility to follow courses in Genetic Epidemiology.

Being able to present a certificate of good conduct, a valid proof of identity, diploma's and/ or relevant registration such as BIG/ RGS are conditions for the appointment.

It concerns a PhD project with an appointment for 4 years. When you are in the possession of a Medical Degree, you will be appointed as research resident with a gross monthly salary which amounts a maximum of € 4.216,- (scale 10), depending on relevant experience and based on a full-time working week of 36 hours. Otherwise the gross monthly salary is € 2.272,- in the first years and increases to € 2.919,- in the fourth year, based on a full-time working week of 36 hours. The terms of employment are in accordance with the Collective Bargaining Agreement for University Medical Centers (CAO UMC).

Erasmus MC

Erasmus MC stands for a healthy population and excellence in healthcare. By conducting groundbreaking work, we aim to push boundaries through leading the way in research, education and healthcare. We have access to the latest equipment and techniques in a state-of-the-art environment.

The Bone Center of the Section Endocrinology of the Department of Internal Medicine is an expert center for rare bone diseases and is combining tertiary care with research performed at the 'state of the art' genetic lab and the lab of calcium and bone metabolism of the Department of Internal Medicine.