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Lipid metabolism is tightly regulated both at the cellular as well as whole-organism level. This regulation ensures that the level of lipids does not increase to toxic levels and that they are available at sufficient amounts for processes requiring them. Disruption of this balance is at the center of several pathological conditions in humans, most notably fatty liver and cardiovascular disease.
Our group is broadly interested in the transcriptional and post-transcriptional regulation of lipid and energy metabolism (e.g Zelcer et al., Science 2009; Zelcer et al. MCB 2014; Sharpe et al. TIBS 2014; Loregger et al. MCB 2015; Nelson et al. Circ Res 2016; Loregger et al. ATVB 2017; van Loon et al. ATVB 2018). Using functional genetic approaches we have recently identified several novel genes which play a previously unrecognized role in key lipid-dependent cellular processes. As such, the central goal of our group is to elucidate the role of these genes in lipid metabolism in vitro at the mechanistic and cellular level (using e.g. RNAseq, metabolomics, mass spectrometry, functional assays), as well as to evaluate their contribution to development of metabolic disease in vivo in mice. As a member of the group you will work within a team and be directly involved in the ongoing research and will also conduct independent experiments.
We are looking for a highly-motivated and enthusiastic technician who has experience and affinity with conducting animal experiments. The applicant should be in possession of an article 9/12 certificate (or equivalent animal handling diploma). Experience with molecular biology and/or cell-based assays is an advantage. Excellent communication skills and the ability to work within an international research group are essential.
We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at AMR means working in an inspiring and professional environment where development is encouraged in every respect.
For an overview of all our other terms of employment, see http://www.werkenbijamc.nl/arbeidsvoorwaarden-amr
The AMC is more than just a hospital. It is a world in which patient care, research and education are integrated, and in which people are always central. It is an academic world full of possibilities for talented individuals that are looking for a place where they can excel. Thinking big, daring to dream, cooperating internationally. And never letting yourself be put off by ‘It’s not possible’ or ’It won’t work anyway’. That is the AMC mentality.
The Zelcer group is located in the Department of Medical Biochemistry. Additional information on our research and group can be found on our website: http://www.zelcerlab.eu/