Transforming growth factor-b (TGF-b) is of key importance in development and maintenance of tissue homeostasis. Work in the Ten Dijke lab is focused on the understanding how TGF-β signaling is perturbed in cancer, and to find new ways to target this pathway for therapeutic gain. In this role you focus on the development of synthetic bioactive molecules that selectively modulate protein-protein interactions or enzymatic activities involved in TGF-b signaling. Examples of such molecules include nanobodies, macrocyclic kinase inhibitors, PROTACs (Proteolysis targeting chimeric molecules) and modulators of the ubiquitin machinery. 

As a team we take a multidisciplinary approach, including high-throughput chemical screens, genetics, (bio)chemistry, cell biology, zebrafish/mouse models and mathematics and bioinformatics.

You hold a PhD in chemical or molecular cell biology. You have expertise in biochemistry and multiple years of experience. You are highly motivated with proven research abilities and an excellent publication record. Furthermore, you are willing and able to work both independently and also collaboratively as part of a team.

Fixed-term contract: 2 years.

You will be employed on the basis of a 36-hour week. Appointment is for two years, with a possible extension. The salary will depend on your qualifications and experience, with a maximum of € 4,361 gross per month based on a full time position (scale 10 of the Collective Labor Agreement for University Hospitals).

LUMC

At the Leiden University Medical Centre (LUMC), we are continually seeking to improve the quality of healthcare. The LUMC aims for excellence in patient care, research, teaching, training and continuing education.

http://www.lumc.nl/

Department Cell and Chemical Biology

The Department Cell and Chemical Biology is equipped with state-of-art facilities for molecular and cell biology, microscopy, chemistry, proteomics, genetics (including DNA editing) and protein chemistry. We believe that curiosity-driven experimental research by talented researchers is at the very heart of true progress in biomedicine.