The department of Preventive Dentistry at ACTA, in collaboration with the VUmc Big Statistics group and the UvA Complexity Science group, is looking for a PhD student in high-dimensional data analysis. The focus will be on constructing predictive models that integrate oral health-related multidimensional datasets.

Although the most prevalent oral diseases – dental caries (tooth decay) and periodontal (gum) disease – are preventable, the worldwide burden of these diseases remains high. Disease risk is influenced by an interplay between the behavioral and biological factors of the individual. Therefore, a more tailored or personalized approach is needed at the level of an individual.

In this 3-year PhD project, we will address the oral cavity as a complex ecosystem at an individual level and model oral health using multi-dimensional data, such as microbiome, metabolome, clinical and biochemical data from a cohort of healthy young individuals. The PhD candidate will develop state-of-the-art methods to jointly analyze large datasets. The resulting model will subsequently serve as basis for a prediction model of oral health outcomes.

We are looking for a PhD candidate with:

• an MSc in either Statistics, Computational Science, Systems Biology or a closely related discipline;
• good statistical knowledge enabling the development of new models and analysis tools;
• experience developing computational and/or statistical models and simulations;
• good programming skills and good R knowledge;
• excellent command of the English language (reading, writing and speaking);
• the ability to explain complex ideas to biologists/non-specialists;
• the ability to work independently, as well as a part of a multidisciplinary team;
• affinity with biology.

Previous knowledge of any of the areas involved in the project, such as mixed-effects models, Bayesian statistics, high-dimensional biological data analysis, are an advantage.

A challenging position in a socially involved organization. The salary will be in accordance with university regulations for academic personnel and amounts €2,325 (PhD) per month during the first year and increases to €2,835 (PhD) per month during the third year, based on a full-time employment. The job profile is based on the university job ranking system and is vacant for at least 1 FTE.
The appointment will initially be for 1 year. After a satisfactory evaluation of the initial appointment, the contract will be extended for a duration of 2 years.

Additionally, ACTA offers excellent fringe benefits and various schemes and regulations to promote a good work/life balance, such as:

• a maximum of 41 days of annual leave based on full-time employment;
• an 8% holiday allowance and 8.3% end-of-year bonus and 
• a solid pension scheme (ABP).

​The Collective Labour Agreement of Dutch Universities is applicable.

University of Amsterdam

With over 5,000 employees, 30,000 students and a budget of more than 600 million euros, the University of Amsterdam (UvA) is an intellectual hub within the Netherlands. Teaching and research at the UvA are conducted within seven faculties: Humanities, Social and Behavioural Sciences, Economics and Business, Law, Science, Medicine and Dentistry. Housed on four city campuses in or near the heart of Amsterdam, where disciplines come together and interact, the faculties have close links with thousands of researchers and hundreds of institutions at home and abroad. 

The UvA’s students and employees are independent thinkers, competent rebels who dare to question dogmas and aren’t satisfied with easy answers and standard solutions. To work at the UvA is to work in an independent, creative, innovative and international climate characterised by an open atmosphere and a genuine engagement with the city of Amsterdam and society.

https://www.uva.nl/en

ACTA

ACTA is the collaboration of the Faculties of Dentistry at Vrije Universiteit Amsterdam and the University of Amsterdam. We focus on all aspects of dentistry: from specialized training to outstanding research and the highest-quality patient care.

Working at ACTA is working on leading international research and training. In 2017, ACTA ranked eighth in the QS World University Rankings. In addition to being an educational and research institution, ACTA also provides healthcare services. You will be working with peers from a variety of disciplines. ACTA has nearly 500 staff members and around 900 students who are taking the Dentistry programme. Around 300 patients visit ACTA every day on average.

https://www.acta.nl/en/