PhD-student in neurobiology of Alzheimer's disease

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PhD-student in neurobiology of Alzheimer's disease

The department of Functional Genomics, part of the Center for Neurogenomics and Cognitive Research a the Vrije Universiteit Amsterdam, and Human Genetics at Amsterdam UMC, is seeking applicants for an PhD-student (onderzoeker in opleiding (OIO)) in neu...

Deadline Published on Vacancy ID 14009
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6 days remaining

Academic fields

Health

Job types

PhD

Education level

University graduate

Weekly hours

36 hours per week

Salary indication

€3017—€3824 per month

Location

De Boelelaan 1117, 1081HV, Amsterdam

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Job description

Alzheimer's Disease pathology is characterized by amyloid-beta plaques and neurofibrillary tau tangles, as well as a loss of synapses and neuronal connectivity. How these pathological protein accumulations lead to neuron dysfunction and neurodegeneration is largely unclear. We have previously found that tau pathology causally disturbs dendrites and synaptic contacts. In this project, you will investigate how metabolic and neurotrophic signaling can be used to restore synaptic contacts between human IPSC-derived neurons with tau pathology and its potential to revert neuronal network dysfunction.

As a PhD student your main tasks and responsabilities are:
  • Cell culture and differentiation of human IPSC-derived neurons;
  • Biochemical assays, CRISPR gene editing and molecular biology;
  • Advanced imaging methods including live cell imaging of synapse and network function, electron microscopy and cellomics;
  • Quantitative analysis of biochemical and imaging data.

Requirements

  • A master degree in biomedical sciences with neuroscience specialization;
  • Hands-on experience with cellular neuroscience, especially molecular signalling pathways is advantage;
  • Hands-on experience with imaging methods. Electron microscopy experience is an advantage;
  • Excellent organizing skills;
  • A strong motivation to pursue a career in science;
  • Proficiency in the English language.

Conditions of employment

  • A flying start to your career in scientific research;
  • Plenty of room for your drive to shape tomorrow's healthcare;
  • Working on large-scale and in-house research, with motivated colleagues from all over the world;
  • You will be employed by Amsterdam UMC Research BV;
  • A contract for 12 months (extension possible for a maximum of 4 years);
  • Salary scale OIO: € 3.017 to € 3.824 gross based on full-time employment (depending on education and experience) and a year-end bonus of 8.3%. Calculate your net salary here;
  • Holiday hours: 190,4 per year for fulltime and a possibility to save additional hours;
  • Pension accrual with BeFrank, a modern, comprehensible and fairly priced pension;
  • For >7 km each way, 100% reimbursement for public transport travel costs and, for private transport, €0.18 per km up to a maximum of 40 km each way;
  • Do you prefer walking or cycling? Take advantage of our good bike scheme. Moreover, you will receive a reimbursement of €0.18 per km.

Watch this video with more information about joining Amsterdam UMC Research BV.

Employer

Amsterdam UMC

The Faculty of Science of the Vrije Universiteit Amsterdam

The Faculty of Science inspires researchers and students to find sustainable solutions for complex societal issues. From forest fires to big data, from obesity to medicines and from molecules to the moon: our teaching and research programs cover the full spectrum of the natural sciences. We share knowledge and experience with leading research institutes and industries, both here in the Netherlands and abroad.

Working at the Faculty of Science means working with students, PhD candidates and researchers, all with a clear focus on their field and a broad view of the world. We employ more than 1,250 staff members, and we are home to around 6,000 students.

About the department(s)
The department of Functional Genomics is part of the Center for Neurogenomics and Cognitive Research in Amsterdam, and the department of Human Genetics at Amsterdam UMC, location VUmc. Our PhD candidates participate in the Graduate School Neurosciences Amsterdam Rotterdam.

Amsterdam UMC Research BV supports non-profit scientific research. In doing so, we provide researchers with everything they need to excel. Our principal investigators (PIs) and project leaders offer support in the field of project management, finance and human resources. In medical scientific research projects, legal support is also provided.

Additional information

During the publication period, applications will be handled continuously. If the vacancy is filled, it will be closed prematurely.

If you have any questions about this position, please feel free to contact Jan van Weering, Team leader Secretory vesicle traffic an recycling, via j.vanweering@amsterdamumc.nl.

For more information about the application procedure, please contact Kim Hooijmans, Recruitment advisor, via k.i.m.hooijmans@amsterdamumc.nl.

A reference check, screening and hiring test may be part of the procedure. Read here whether that applies to you. If you join us, we ask you for a VOG (Certificate of Good Conduct).

Internal candidates will be given priority over external candidates in case of equal suitability.

Acquisition in response to this vacancy is not appreciated.

Together @ Amsterdam UMC

Amsterdam University Medical Centers is a leading medical center that combines complex high-quality patient care, innovative scientific research and education of the next generation committed health care professionals. Together we discover the healthcare of tomorrow.

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6 days remaining