PhD candidate Synapse Research Institute to unravel the bleeding phenotype of several patient populations with congenital bleeding disorders

The main focus of the thesis trajectory is to unravel the bleeding phenotype of several patient populations with congenital bleeding disorders. Hemostasis is a physiological process with the aim to prevent or stop bleeding. This process includes the interaction of many enzymes, proteins, blood cells and endothelial cells. When one of these components is insufficient or absent and not adequately compensated by another component, a person is prone to bleed. This can cause severe co-morbidity, reduced quality of life and even decreased survival. Are you our new PhD candidate?

This current PhD position compromises a clinical scientific collaboration between Radboudumc and the not-for-profit scientific organization of Synapse Research Institute. Synapse Research Institute has developed a novel hemostasis assay which can measure the breakdown of a blood clot, the plasmin generation assay. This assays will be performed in all patient categories, once they have been recruited. Subsequent clinical information from the bleeding tendency and quality of life will be collected as well.

The Hemophilia Treatment Centre of the Radboudumc has a large cohort of patients with congenital bleeding disorders. Hence, most of the activities of the PhD will take place in the clinical setting of the hemophilia treatment centre. You will work together in a team with a colleague PhD from the Laboratory of Hematology to perform the different hemostasis assays. You will be appointed by Synapse Research Institute and your primary working place will be the Radboudumc.

Tasks and responsibilities

• Co-writing documents for the clinical research for approval from the medical ethical committee.
• Successfully complete the BROK course.
• Recruitment of patients for the clinical study.
• Develop several competences as a PhD student, participate in PhD courses.
• Analyse clinical data and data from hemostasis assays.
• Work together with the PhD from the Laboratory of Hematology to validate the plasmin generation assay.
• Write scientific publications.
• Present your scientific work during (inter)national congresses.
• Participate in education from the department of Hematology.
• Collaborate with the supervising team (promotors and co-promotors) and colleague PhD students, with public (Radboudumc) and private (Synapse) partners.

Our new PhD candidate is successfully graduated in the master Medicine (basis doctor) and can speak and write excellently in Dutch and English. You are a team player, with excellent communication skills to participate in meetings with colleagues from public (Radboudumc) and private (Synapse) partners.

Furthermore, you recognize yourself in the profile below:

• You have developed skills to communicate and recruit patients for clinical studies.
• You have a sincere interest in hemostasis and clinical implications.
• You are highly motivated to analyze the generated data and translate the results into public scientific papers.

You will be appointed by Synapse Research Institute and your primary working place will be the Radboudumc. Upon commencement of employment, you will start at scale 10A, step 0 (€ 3.017 based on a full-time appointment). Over a maximum period of 4 years, you will progress to scale 10A, step 3 (€3.824 based on a full-time appointment). You will also receive an 8% holiday allowance, an 8.3% end-of-year bonus, an 47% to 72% bonus for working unsocial hours and 176 vacation hours per year based on a fultime working week.

You will be appointed by Synapse Research Institute, and your place of work is the Radboudumc, department of hematology. In the department of hematology, the Hemophilia Treatment Centre is situated. The Hemophilia Treatment Centre is a tertiary expertise centre with a broad accessibility region providing health care for many patients with bleeding disorders in the South-East part of The Netherlands. Most of the healthcare is provided in the out patients clinical ward and day treatment ward.

One of the most important activities in which laboratory results meet clinical implication, are the multidisciplinary meetings with representatives of the Laboratory of Hematology, (pediatric) hematologist, laboratory analysts and hemophilia nurses come together. As a PhD student, performing clinical scientific research, you will have an essential role in connecting with all these disciplines. During periods of patient recruitment, you will be working in the Radboudumc, this will be alternated by periods of analyzing data and writing scientific publications either in the Radboudumc or at home.

Synapse Research Institute
Synapse research Institute is a not-for-profit research institute with its ultimate goal to diagnose and prevent episodes of bleeding and thrombosis. Synapse is originally a spinoff from the University of Maastricht but has become a private research institute in 2009. Synapse Research Institute is seen worldwide as one of the most innovative institutes in the field of hemostasis diagnostics and is the founder of calibrated thrombin generation, calibrated plasmin generation and many more.
Synapse Research Institute hosts many academically trained personnel from technician up to Professors and has supervised over 20 PhD students to obtain their doctor’s degree. Synapse Research Institute is also a training center where scientists from all over the world visit to learn new techniques that were founded within Synapse.

Radboudumc
Welcome to Radboud university medical center (Radboudumc), where scientific breakthroughs are born through the curiosity and passion of our collaborating researchers in a vibrant environment. We believe trust and excitement are crucial elements to achieving our goals, and we approach our research as teams and with the utmost rigor to make a significant impact on health and healthcare. Our researchers are driven by their fascination with the biological, psychological, and sociological mechanisms underlying health and healthcare. They collaborate with partners from all over the world to improve health outcomes for all. Radboudumc unites patient care, research, education, and corporate learning, which allows us to approach our mission to shape the health and healthcare of the future in an innovative and person-centered way.

Our ambition is to lead the way in the pursuit of prevention, sustainability, meaningful care. We believe that through our research, we can significantly improve the health and well-being of society. Join us on our mission to make a difference in healthcare. Become a part of our community of gifted researchers, professionals or patient partners who are dedicated to making a real impact on population health and healthcare.

Read what it is like to do a PhD at the Radboud University Medical Center.

Any questions? Or wondering what it is like to work at Radboudumc or Synapse Research Institute? For Radboudumc please contact Saskia Schols, PhD, MD, Sanna Rijpma, PhD EuSpLM or An Stroobants, PhD EuSpLM. For Synapse Research Institute please contact Bas de Laat, general director. Use the Apply button to submit your application.

Any questions? Or wondering what it is like to work at Radboudumc or Synapse Research Institute? For Radboudumc please contact Saskia Schols, PhD, MD, Sanna Rijpma, PhD EuSpLM or An Stroobants, PhD EuSpLM. For Synapse Research Institute please contact Bas de Laat, general director. Use the Apply button to submit your application.