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PhD Position: Unravelling the genetics of congenital heart disease using large-scale genomic approaches

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PhD Position: Unravelling the genetics of congenital heart disease using large-scale genomic approaches

WKZ is seeking a PhD candidate to study the genetic architecture of congenital heart disease - the most common birth defect workdwide.An exciting opportunity to contribute to cutting-edge research bridging genomics, bioinformatics, and clinical care.

Deadline Published on Vacancy ID 2025-6080
Apply now
2 days remaining

Academic fields

Health

Job types

PhD

Education level

University graduate

Weekly hours

32—36 hours per week

Salary indication

max. €3939 per month

Location

Heidelberglaan 100, 3584CX, Utrecht

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Job description

  • Conduct large-scale genetic association studies in CHD
  • Analyze genetic variants using state of the art bioinformatic tools
  • Integrate genetic findings with expression data from cardiac development to identify causal genes and biological pathways.
  • Develop and apply polygenic risk scores to predict cardiovascular and neurodevelopmental outcomes.
  • Design and implement bioinformatic pipelines to support these analyses.

Requirements

  • A Master’s degree in Bioinformatics, Biomedical Sciences, Medicine, Genetics, or a related field.
  • Strong analytical thinking and problem-solving skills.
  • Excellent communication skills and a collaborative mindset.
  • Experience with genetics, biostatistics, and the analysis of NGS and array genotyping data (preferred).
  • Experience with Python, R, and Bash (preferred).
  • Familiarity with sequence alignment tools, variant calling, and handling large-scale genomic and multi-omics datasets (preferred).

Conditions of employment

The maximum salary for this position (32 - 36 hours) is € 3.939,00 gross per month based on full-time employment.

In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses and career opportunities. The terms of employment are in accordance with the Cao University Medical Centers (UMC).

Department

You will be embedded in an interdisciplinary team within the Departments of Pediatric Cardiology and Clinical Genetics, working closely with a national and international network of pediatric cardiologists, clinical geneticists, embryologists, and bioinformaticians.

Our research is conducted in collaboration with Amsterdam UMC and the Hubrecht Institute, focusing on large-scale genomics and functional validation of novel CHD genes. Neurodevelopmental and neuroimaging outcomes are studied in partnership with the Department of Neonatology. By integrating genomic and transcriptomic data, our goal is to advance both the scientific understanding and clinical management of congenital heart disease.

Additional information

Contact our colleague:
Hans Breur
088-7555459
H.Breur@umcutrecht.nl

Werken bij UMC Utrecht

Werken in het UMC Utrecht betekent werken op het snijvlak van onderzoek, onderwijs, zorg en techniek. In onze academische setting leren en innoveren we continu en zijn nieuwe ontwikkelingen altijd binnen handbereik.

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