Postdoc immuunmonitoring voor myeloïde maligniteiten

Our myeloid research team has ample experience in identifying, characterizing and quantifying malignant myeloid cells in patients with several hematological malignancies such as acute myeloid leukemia (AML), chronic myeloid leukemia (CML) and myeloid dysplastic syndromes (MDS). The malignant cells are measured by flow cytometry using different CD-marker panels specific to the myeloid cells.

It has become more and more clear that the immune environment in the bone marrow is very important to achieve good and prolonged remissions. Hence, many different CD-marker panels are currently used to measure specific functional cell populations such as T-cell, B-cell and NK-cell subsets.

As we have a large number of data of different immune monitoring panels measured in large patient cohorts, we want to make an inventory of current panels and results, and develop the most optimal panels for each of the different research questions of different immune cell subsets. These panels need to be validated and bioinformatics pipelines designed for standardized analysis of the data.

In order to achieve the above a non-academic tenure track Scientist is required and requested.

Your responsibilities will be to:

• make an inventory of our immune monitoring data and knowledge of literature;
• design flow cytometry panels (conventional and/or spectral) for different research questions and specific immune cell subsets;
• validate the panels and optimize (computational) analysis.

The project will require at least 3 years. Within this period the following goals are expected to be achieved:

1. Optimal flow cytometry panels for all relevant immune cell subsets.
2. Pipeline for analysis of the flow cytometry data to be used and adjusted for different research questions related to immune monitoring.

You have:

• a PhD;
• extensive technical experience in flow cytometry (conventional and spectral);
• experience in setting up flow cytometry panels;
• affinity with bioinformatics.

• A flying start to your career in scientific research.
• Plenty of room for your drive to shape tomorrow's healthcare.
• Working on large-scale and in-house research, with motivated colleagues from all over the world.
• You will be employed by Amsterdam UMC Research BV.
• A contract for 12 months, with the intention to extend for a total of 3 years.
• Salary scale 10: € 3.598 to € 5.669 gross based on full-time employment (depending on education and experience) and a year-end bonus of 8.3%. Calculate your net salary here.
• Holiday hours: 190.4 per year for fulltime and a possibility to save additional hours.
• Pension accrual with BeFrank, a modern, comprehensible and fairly priced pension.
• For >7 km each way, 100% reimbursement for public transport travel costs and, for private transport, €0.18 per km up to a maximum of 40 km each way.
• Do you prefer walking or cycling? Take advantage of our good bike scheme. Moreover, you will receive a reimbursement of €0.18 per km.

Watch this video with more information about joining Amsterdam UMC Research BV.

Amsterdam UMC Research BV supports non-profit scientific research. In doing so, we provide researchers with everything they need to excel. Our principal investigators (PIs) and project leaders offer support in the field of project management, finance and human resources. In medical scientific research projects, legal support is also provided.

Watch the video to find out more.

The department of Hematology at Amsterdam UMC, chaired by Prof. Sonja Zweegman, location VUmc is specialized in the treatment of patients with hematological malignancies. Within the Hematology laboratory, of the Cancer Center Amsterdam, researchers are investigating leukemia at the molecular and cellular level, in close collaboration with the clinicians.