Misregulation of TGF-b signalling has been implicated in many different diseases, including cancer, fibrosis and cardiovascular diseases. We have performed genetic gain and loss of function genetic and proteomic screens to identify novel druggable regulators of TGF-β pathways. In this project the mechanism of action and importance in disease of these novel regulators will be elucidated. In addition, we will harness the ubiquitin machinery (e.g. using PROTACs) to induce degradation of critical pro-oncogenic factors. You will contribute to this project.

We are searching for a highly motivated and experimentally talented scientist with drive to answer important fundamental research questions. You should hold a recent PhD and have a strong background in biochemistry and/or molecular cell biology. In addition, you have previous experience in signal transduction or chemical biology. Reporting and publishing the results in high impact scientific journals and at international conferences is expected.

Fixed-term contract: min. 2 years.

You will be employed on the basis of a 36-hour week. Appointment will be for 2 years, possibly to be extended. The salary will depend on your qualifications and experience, with a maximum of € 4,481 gross per month based on a full time position (scale 10 of the Collective Labor Agreement for University Hospitals).

LUMC

The LUMC is a center for medical innovation that aims to improve patient care through leading international research. So as to also provide our patients with a safe and friendly environment, we need doctors, medical care specialists, support staff and academic researchers.

epartment of Cell and Chemical Biology

The Department of Cell and Chemical Biology is equipped with state-of-art facilities for molecular and cell biology, microscopy, chemistry, proteomics, genetics and protein chemistry. Furthermore, the LUMC is known for its innovative academic medical research with an multidisciplinary approach. We break new ground by working together.