You will be working on a project focusing on investigating the cellular plasticity (i.e. capacity to change identity) of human pancreatic islet cells in the context of type 1 diabetes. This project will be run in collaboration with Dr Raphael Scharfmann (INSERM, Paris, France). In addition, you will be involved in the isolation of human pancreatic islets for transplantation within a GMP environment contributing to the current clinical islet transplantation program in our institute. Islets and non-islet tissue that cannot be used for transplantation can often be used for research purposes.

·        You hold a PhD in biomedical sciences or equivalent

·        You will work with (primary) human pancreatic cells

·        You will also be involved in the isolation of human pancreatic islets for transplantation

·        View more project information here

You are a motivated and dedicated candidate who holds a PhD degree in biomedical sciences (or equivalent). Preferrably, you have experience in (primary human) cell culture, RNA and protein work (Q-PCR, RNA-sequencing, immunohistochemistry, flow cytometry), cell imaging techniques (confocal, live imaging), and in particular in bioinformatics (use of R) and big data analysis (of (single-cell) transcriptomics, ideally). We are looking for someone who is flexible and can work well together.

Fixed-term contract: Four Years.

You will be employed on the basis of 36 hours per week. Appointment is for one year, with an extension of two years. Your salary is based on your education and experience and is a maximum of  € 4,481  gross per month for a full time position (scale 10 in the Collective Labour Agreement for University Hospitals).

LUMC

At the Leiden University Medical Center, we continuously work on improving patient care. We invest in groundbreaking, international research and work with the latest equipment. Together with our team of doctors, medical specialists, teachers, academic researchers and supporting staff, we aim for the best quality in health care, education and international research. And we need you to realize our goals!

Department of Internal Medicine /Nephrology

Within the LUMC, the Department of Internal Medicine /Nephrology carries out basic, translational and clinical research on kidney, pancreas and islet transplantation. Specific basic research focuses on diabetes, transplantation immunology and vascular medicine.