Microengineered physiological systems (MPSs), also known as organs-on-chip (OoCs) have recently been introduced to emulate key features, functions and interactions of specific human tissues and organs. The latest progress in OoC technology has rapidly led to the development of complex in-vitro biological models and multi-organ systems. Nevertheless, constant innovations in microfluidic OoC development drive the need for additional dedicated instrumentation and supplementary modules. In this respect, CMOS technology can be leveraged to enable microsystems with advanced readout functionality that can be seamlessly integrated within OoC devices. 

The goal of this project is to develop of a CMOS-based analytical microsystem for heart-on-a-chip applications. The project will explore novel techniques and approaches to achieve holistic integration of active electronics with sensors and porous membranes in heart-on-chip platforms. The candidate will design and fabricate custom CMOS readout instrumentation and integrate the designed microchips in system demonstrators based on an OoC platform already established at TU Delft.  

The candidate should hold a Master’s degree in Electrical and Electronic Engineering with specialisation in microelectronics and/or microfabrication, or equivalent. Excellent knowledge of electronic circuits and systems and electronic instrumentation with practical laboratory experience is essential. Experience with IC design and design tools (e.g. Cadence) is recommended, as well as knowledge of MEMS technology and clean room experience. The candidate will be working across two well established research groups (Bioelectronics – BE, and Electronic Components, Technology and Materials – ECTM) of the Microelectronics department of TU Delft, hence a collaborative spirit and effective communication skills (pre-senting, reporting, moderating) are vital for successful collaboration. 

TU Delft is at the forefront of organ-on-chip development as part of the Netherlands Organ-on-chip Initiative (NOCI) and one of the partners of the Institute for human Organ and Disease Model technologies (hDMT). The PhD candidate will benefit from and contribute to extend partnerships with national and international collaborators, including Erasmus Medical Centre (EMC) the Leiden Medical Centre (LMC), Philips Research, NXP Semiconductor, X-FAB, Multi Channel System among others.

Fixed-term contract: 4 years.

TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers childcare and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities. 

As a PhD candidate you will be enrolled in the TU Delft Graduate School. TU Delft Graduate School provides an inspiring research environment; an excellent team of supervisors, academic staff and a mentor; and a Doctoral Education Programme aimed at developing your transferable, discipline-related and research skills. Please visit www.tudelft.nl/phd for more information. 

Technische Universiteit Delft

Delft University of Technology (TU Delft) is a multifaceted institution offering education and carrying out research in the technical sciences at an internationally recognised level. Education, research and design are strongly oriented towards applicability. TU Delft develops technologies for future generations, focusing on sustainability, safety and economic vitality. At TU Delft you will work in an environment where technical sciences and society converge. TU Delft comprises eight faculties, unique laboratories, research institutes and schools.

Faculty Electrical Engineering, Mathematics and Computer Science

The Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS) is known worldwide for its high academic quality and the social relevance of its research programmes. The faculty’s excellent facilities accentuate its international position in teaching and research. Within this interdisciplinary and international setting the faculty employs more than 1100 employees, including about 400 graduate students and about 2100 students. Together they work on a broad range of technical innovations in the fields of sustainable energy, telecommunications, microelectronics, embedded systems, computer and software engineering, interactive multimedia and applied mathematics.

https://www.tudelft.nl/en/eemcs/the-faculty/