We are looking for a highly motivated PhD candidate to join the Biomolecular Electron Nanoscopy group of Dr. Arjen Jakobi at the Department of Bionanoscience, Kavli Institute of Nanoscience Delft (http://cryoem.tudelft.nl). Our laboratory studies molecular mechanisms of the host machinery mediating defense against invading pathogens using a structural biology approach that integrates cryo-EM imaging with methods from biophysics, protein biochemistry and cell biology. We also develop and apply new approaches for cryo-EM imaging to facilitate meeting our research goals.

You will express and purify key protein complexes mediating intracellular immunity and determine their structure using state-of-the-art structural biology techniques. This project will also provide the student with a unique opportunity to conduct high-resolution electron cryo-tomography in order to structurally characterise these complexes in their native cellular context. Training will be provided in molecular biology, protein biochemistry, cryo-EM and associated image-processing techniques as well as X-ray crystallography. Depending on the experience and interest of the applicant, there will be flexibility to focus the project towards cellular or molecular structural biology. Possible projects and further details will be discussed during the interviews. A contract for 4 years will be offered to the successful candidate.

We offer a dynamic, supportive and collegial environment with access to state-of-the art facilities. The Department of Bionanoscience will provide outstanding infrastructure for nanofabrication, fluorescence microscopy molecular/cell biology, biochemistry, state-of-the-art electron microscopy and high-performance computing for image processing.

The candidate should have a degree in biology, biochemistry, chemistry, physics or a related field, with research experience in molecular biology and enthusiasm for working at the interface of biology, chemistry, and physics. Expertise in recombinant protein expression is strongly desired. Previous experience with electron microscopy or X-ray crystallography is beneficial, but not required. We are looking for a candidate with a high level of intellectual creativity and genuine interest in fundamental research, who has the motivation and ability to work in an international and interdisciplinary team. Good communication skills in English are essential.

Fixed-term contract: 4 years.

The TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. Coming to Delft Service organizes diverse events for new international employees and their accompanying partners, like Partner Career Workshops and Dutch Culture Workshops. Located on campus are the International Children’s Centre and an international primary school which are subject to availability as well as several bilingual schools in the nearby surrounding. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.

As a PhD candidate you will be enrolled in the TU Delft Graduate School. TU Delft Graduate School provides an inspiring research environment; an excellent team of supervisors, academic staff and a mentor; and a Doctoral Education Programme aimed at developing your transferable, discipline-related and research skills. Please visit www.tudelft.nl/phd for more information.

Technische Universiteit Delft

Delft University of Technology (TU Delft) is a multifaceted institution offering education and carrying out research in the technical sciences at an internationally recognised level. Education, research and design are strongly oriented towards applicability. TU Delft develops technologies for future generations, focusing on sustainability, safety and economic vitality. At TU Delft you will work in an environment where technical sciences and society converge. TU Delft comprises eight faculties, unique laboratories, research institutes and schools.

Faculty Applied Sciences

The Faculty of Applied Sciences is the largest faculty of TU Delft, with around 550 scientists, a support staff of 250 and 1,800 students. The faculty conducts fundamental, application-oriented research and offers scientific education at the bachelor, master and doctoral levels. The faculty is active in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Applied Physics.

The Department of Bionanoscience, part of the Faculty of Applied Sciences at Delft University of Technology and part of the Kavli Institute of Nanoscience Delft (http://kavli.tudelft.nl/), is dedicated to pioneering, fundamental research at the interface between physics and biology. This young, international department was established in 2010 and has since expanded to currently 17 faculty members. The department offers excellent general facilities, including an advanced optical microscopy facility, a cryo-EM facility, extensive general cell biology and biochemistry facilities, and a large cleanroom facility, the Kavli Nanolab Delft. The department strives for a collegial, nourishing, and inclusive environment.