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We wish to combine our scientific excellence in organic chemistry and chemical biology with the world-class research in neuroscience at DCN. This combination provides an outstanding opportunity to set-up a new research effort in medicinal chemistry/neurochemistry. The range of possible research areas is broad, but should be strongly driven by a molecular chemistry approach to solving longstanding molecular challenges in neuroscience. Examples of possible research lines include the exploration of (small) molecules modulating targets in neurons, synapses and neural networks, and the use of chemical biology approaches to study key aspects of neurodegenerative diseases such as protein aggregation or the search for biomarkers. A strong datascience component may be included, given the complexity and amount of data likely to be encountered.
The ideal candidate for this position is a medicinal chemist/neurochemist who has a PhD degree in chemistry or biochemistry and uses chemical biology and/or medicinal chemistry approaches to study and modulate molecular mechanisms underlying neurological or neurodegenerative diseases.Fixed-term contract: indefinite period.
We want to get the best out of science, others and ourselves. Why? Because this is what the world around us desperately needs. Leading research and education make an indispensable contribution to a healthy, free world with equal opportunities for all. This is what unites the more than 22,000 students and 5,000 employees at Radboud University. And this requires even more talent, collaboration and lifelong learning. You have a part to play!
The Faculty of Science is a complete, student-oriented science faculty where research and education are closely intertwined. The faculty aims to form an academic community with an international character, where staff members from different backgrounds can combine their talents with the common goal of belonging to the leading science faculties in Europe.
You will be appointed as a Full Professor at the Institute for Molecules and Materials (IMM). IMM is a research institute in chemistry and physics, which fosters interdisciplinary research. Its mission is to design and create functional molecules and materials to fundamentally understand their behaviour. IMM comprises 19 research groups active in areas ranging from condensed matter science to organic chemistry and chemical biology. We focus on fundamental research with an open eye for societal applications and educate the next generation of leaders in science and innovation. IMM distinguishes itself from similar institutes by intensive collaborations and interactions between chemists and physicists and between experimentalists and theorists. IMM has a strong infrastructure including large user facilities such as the High Field Magnet Laboratory (HFML), the Free Electron Laser facility FELIX and part of the uNMR-NL facilities.
Chemical biology is a broad research area applying chemical techniques, such as synthetic organic chemistry and analytical methods, to study and modulate biological systems. Chemical biology at IMM benefits from the many close connections between (organic) chemistry groups and research teams at the Radboud Institute for Molecular Life Sciences (RIMLS), the Radboud university medical center (Radboudumc), and the Donders Institute for Neuroscience (DCN). This allows us to cover challenging research projects in a unique way, from molecule to man to patient population. We seamlessly integrate organic synthesis of complex biologically relevant molecules with new omics technologies (including proteomics, metabolomics and RNA-seq), and we use both in vitro and in vivo biochemical approaches to study the role of target molecules in their physiological, intracellular environment. Highlights include unravelling the role and mode of action of sialic acids, novel methods for targeting intracellular proteins, screening new drug targets and subsequent hit-to-lead optimisation and the development of bio-orthogonal click reactions. Current research topics include new methods for single-cell analysis, the discovery of underlying mechanisms of motor neurodegenerative disorders, and the identification of molecules that play a role in the development of the brain. There is also a clear potential for new developments in (chemical) datascience, where we profit from the strong interaction with computational neuroscience at DCN and the state-of-the-art Radboudumc technology centres in bioinformatics, microscopy and mass spectrometry in RIMLS.
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