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This research project contributes to the Biobased Value Circle objectives by focusing on the production of biobased materials for medical applications.
Fibroin is the basic component of silk, a natural and biodegradable material with exceptional mechanical properties, highly suited for biomedical applications. Because recovering and regenerating of silk fibroin from its natural sources alters its intrinsic physical and mechanical properties, there is the need to establish an efficient production platform for soluble fibroin monomers, which can then be polymerized and processed in different ways depending on the application. Fibroin are large, repetitive proteins and this poses serious challenges to their production. Plant-based expression systems are flexible and versatile platforms for recombinant protein production. Most importantly, they are especially suited for the expression of highly repetitive constructs due to their genetic stability compared to microbes.
Results: The goal of this project is to establish a tobacco cell culture as a reproducible production system for fibroin. Two main approaches will be followed: on one side, the metabolism of plant cells will be optimized towards the high-level production of these repetitive proteins; on the other side, different fusions and expression strategies will be explored to increase fibroin solubility, accumulation and recovery. In collaboration with Fibrothelium GmbH (Germany), we will test the mechanical, physical and biological properties of the recombinant proteins and evaluate how to implement these raw materials into the established manufacturing routines of a medical device supplier.
The general requirements for all Biobased Value Circle positions apply here, i.e.:
Furthermore, the position-related requirements are:
Maastricht University is renowned for its unique, innovative, problem-based learning system, which is characterized by a small-scale and student-oriented approach. Research at UM is characterized by a multidisciplinary and thematic approach, and is concentrated in research institutes and schools. Maastricht University has around 20,000 students and 4,700 employees. Reflecting the university's strong international profile, a fair amount of both students and staff are from abroad. The university hosts 6 faculties: Faculty of Health, Medicine and Life Sciences, Faculty of Law, School of Business and Economics, Faculty of Science and Engineering, Faculty of Arts and Social Sciences, Faculty of Psychology and Neuroscience. http://www.maastrichtuniversity.nl/
The Aachen-Maastricht Institute for Biobased Materials (AMIBM) is a European, cross-border, research institute focusing on the development of advanced biobased materials. AMIBM strives for groundbreaking conversion of biomass to biobased materials and into product applications.
AMIBM is located in the Netherlands on the Brightlands Chemelot Campus in the Dutch Province of Limburg and has a branch office in Germany (AMIBM e.V.), and conducts innovative fundamental, applied and translational research by creating synergies between academia and industry.
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