Within the Laboratory of Proteomics at the department of Molecular Hematology we have an open position for a post-doc to set up targeted plasma proteomics approaches for absolute quantification of plasma proteins, with specific emphasis on immunoglobulins and coagulation factors.

Project
Mass spectrometry (MS)-based proteomics is a technology that holds great promise in discovering biomarkers in body fluids. In this project you will develop and implement PRM-based targeted proteomics approaches based on heavy-labelled peptides as well as on SILAC-based protein standards to identify and quantify molecular signatures that are associated with disease. Within the project we will focus on 1) profiling of immunoglobulins as an important aspect in dissecting acquired immunity in response to pathogen exposure, auto-immunity, allo-immunization during pregnancy or after blood transfusion as well as for therapeutic drug monitoring of patients that are receiving monoclonal antibody therapy and 2) profiling of coagulation factors as a promising approach to diagnose congenital bleeding disorders and to assess the risk for bleeding and thrombosis in individual patients.

• A PhD degree in chemistry, biology, (bio)molecular/biomedical/pharmaceutical sciences or equivalent;
• Experience in quantitative (prote)omics, data statistics, bioinformatics, and data reporting/visualization;
• Problem-solving skills and capability to apply knowledge and experience to address complex challenges;
• Good communication skills in English;
• The capability to work efficiently independently, but also as part of a multinational team.

Fixed-term contract: 4 years.

We offer unique research opportunities in a dynamic environment. Nowhere else in the world you will find an organization that combines medical, pharmaceutical, diagnostic and scientific research under one roof.  In addition to a challenging project in a multi-disciplinary and enthusiastic team we offer:

• salary and working conditions conform CAO Sanquin;
• temporary position for the duration of 4 years;
• a full time contract of 36 hours per week;
• 8,33% end-of-year bonus;
• 8,33% holiday allowance;
• partial reimbursement of travel expenses;
• pension plan with Pensioenfonds Zorg & Welzijn (PFZW);
• collective discounts on various insurances;
• at fulltime employment (36 hours) 201 hours of leave per annum.

Sanquin

Bloed is leven
Sanquin heeft als een van de weinige organisaties ter wereld zowel medische als diagnostische én wetenschappelijke activiteiten onder één dak, allen op het gebied van bloed. Met ruim 2.000 betrokken collega’s en 345.000 donors geven we 300.000 patiënten per jaar een beter leven.

Molecular Hematology

The Laboratory of Proteomics is embedded in the department of Molecular Hematology and is a frontrunner in applying state-of-the-art mass spectrometry-based proteomics within the scientific framework of Sanquin Research. We are a vibrant, international group of 35-40 colleagues (consisting of group leaders, postdocs, PhD students and technicians) that study the various aspects of hemostatic networks. Our department has academic affiliations with high-ranking universities in the Netherlands, such as Utrecht University and the University of Amsterdam. The department’s research program benefits from excellent research facilities, which include the latest technology for biomolecular mass spectrometry, imaging and cell sorting.