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Research into the human genome has been one of the fastest evolving areas of science, partly with the purpose of finding new evidence for links between the genome and diseases. As a PhD Candidate, you will put your knowledge of biology into practice by aiming to understand the genome architecture and the biophysical mechanisms that drive it.
One of the major challenges in biology is the process of organising the genome while tightly regulating its function. Our lab focuses on understanding the genome architecture and the biophysical mechanisms that drive it. In this project, you will use molecular biology and (single-molecule) microscopy techniques, with the aim to provide new insights into the interplay between post-translational modifications, chromatin folding, and phase separation on and around the genome. This will set the stage for understanding chromatin misregulation in disease. We are looking for a scientist with a fundamental interest in chromatin organisation who is open to conducting multidisciplinary research.
You will work as a member of the Cell Biology group at RIMLS-FNWI, under the supervision of Dr Jorine Eeftens, and in close collaboration with other group members. The project is embedded within an ambitious and interactive research department, with expertise in various omics approaches and advanced cell culture. There will be ample opportunities for collaboration within and outside the department. As part of your PhD training, you will assist in one or two courses a year and supervise BSc and MSc students within the context of your project. These educational duties may comprise up to 10% of your appointment.
Fixed-term contract: 4 or 5 years.
The Radboud Institute for Molecular Life Sciences (RIMLS) is a leading interfaculty research institute of the faculties of Science (FNWI) and Medicine (Radboud university medical center). The overarching aim of RIMLS is to decipher molecular mechanisms of disease. Research areas of RIMLS-FNWI include epigenetics, stem-cell and developmental biology, computational biology, and biophysics. The central research theme is regulation of gene expression during development and in health and disease. RIMLS-FNWI operates its own wet-lab, microscopes and computational facilities. This fundamental and applied research in medical biology and molecular life sciences has clear links to biochemical research performed at the Institute for Molecules and Materials and other institutes of the Faculty of Science, as well as to more clinically oriented research programs at departments within the Radboud university medical center.
RIMLS-FNWI actively contributes to teaching activities at Radboud University. RIMLS-FNWI currently employs approximately 50 researchers (including 30 PhD candidates and postdoctoral researchers) and provides a vibrant and international working environment. The institute actively participates in many European and worldwide consortia and collaborations.
We want to get the best out of science, others and ourselves. Why? Because this is what the world around us desperately needs. Leading research and education make an indispensable contribution to a healthy, free world with equal opportunities for all. This is what unites the more than 24,000 students and 5,600 employees at Radboud University. And this requires even more talent, collaboration and lifelong learning. You have a part to play!
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