The innate immune system is crucial to protect the body against pathogens. On the other hand, innate immune mechanisms are sometimes unintentionally activated by self-derived ligands. Such a sterile inflammatory response occurs in auto-inflammatory and autoimmune disorders and it is a hallmark of the tumor microenvironment. How does the innate immune system discriminate between the body's own molecules and microbial ones to ensure an effective immune response against invaders while avoiding self-directed inflammation? What are the molecular mechanisms that suppress unwanted activation of innate immunity? How can we harness sterile inflammation to boost the body's anti-tumor immune response? If you are interested in these fundamental questions, come and strengthen our team! We are using molecular, biochemical and cell-based approaches in our research. The advertised project focuses on nucleic acid sensing and the type I interferon response and has a strong molecular basis. The lab is embedded within the department of Immunology and closely collaborates with the Cell and Chemical Biology Department at the LUMC. The lab is also part of the Institute for Chemical Immunology.
· You will use biochemical and molecular approaches to study innate immune mechanisms that control viral infection and sterile inflammation
· You will set up in vitro and/or cell-based assays to identify small molecules that target and modulate innate immune pathways
· Your work is relevant to autoinflammatory diseases, autoimmune disorders, and anti-tumor immunit
We are looking for an excellent and ambitious candidate with a PhD in biomedical sciences or a related field, and with a proven track record of achievement. Experience in the field of biochemistry and protein analysis is an absolute must. The project will involve recombinant protein expression, various in vitro protein-based assays, high-throughput screening and cell-based assays. Knowledge of RNA biology, immune-related mechanisms, as well as proteomic research portals and software is highly desirable. You are able to work independently as well as in a multi-disciplinary team, and you have outstanding organizational skills. We expect a pro-active and goal-oriented attitude and are looking for someone that can drive multiple aspects of a project. Excellent communication skills in English are essential. International candidates are encouraged to apply.
Fixed-term contract: Appointment is for one year, with the possibility of extension for another year.
You will be employed on the basis of 36 hours per week. Appointment is for one year, with the possibility of extension for another year. Your salary is based on your education and experience and is a maximum of € 4,615 gross per month for a full time position (scale 10 in the Collective Labour Agreement for University Hospitals).
At the Leiden University Medical Center, we continuously work on improving patient care. We invest in groundbreaking, international research and work with the latest equipment. Together with our team of doctors, medical specialists, teachers, academic researchers and supporting staff, we aim for the best quality in health care, education and international research. And we need you to realize our goals!
Your career at the LUMC
The LUMC offers opportunities to maintain and develop your knowledge and skills. We offer internal courses and in-service training to help you with your personal development. We also offer services for mobility and career advice.
See our website for more information on the Annemarthe van der Veen group.
Acquisition as a result of this vacancy is not appreciated.
dr. Annemarthe van der Veen, assistant professor, department of Immunology
Telephone: +31 (0)71 526 29 08
Leiden University Medical Center (LUMC)
Albinusdreef 2, 2333 ZA, Leiden
This application process is managed by the employer (Leiden University Medical Center (LUMC)). Please contact the employer for questions regarding your application.
Please contact the employer for questions regarding your application.
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Make sure to apply no later than 26 Dec 2021 23:59 (Europe/Amsterdam).
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