As a member of our research group you will investigate mechanisms of post-translational protein modification by ubiquitin and SUMO (Small Ubiquitin-like Modifier). You will study the important roles of SUMO and ubiquitin during the cell cycle at a proteome-wide level and at the level of individual target proteins. Our group is interested in the mechanisms and functional consequences of post-translational protein modification by SUMO and ubiquitin. We are a multi-disciplinary team and integrate biochemistry, cell biology, proteomics and genomics approaches and employ state-of-the art microscopes and mass spectrometers to obtain novel insights in SUMO- and ubiquitin signal transduction (Kumar et al. 2022 Gut). We have developed innovative methodology to study SUMOylation and ubiquitylation in a cell-wide manner. We focus on the role of these protein modifications during the cell cycle.

We are looking for an enthusiastic, motivated and result driven postdoc. You hold a PhD degree in biomedical sciences or a similar field and have an excellent track-record in molecular cell biology obtained in a leading laboratory. Experience with ubiquitin-like proteins, cell cycle progression, protein biochemistry,  proteomics or mass spectrometry will be a distinct advantage. You should be creative and professional and excellent written and oral communication skills are a must.

Fixed-term contract: 2 years.

You will be employed on the basis of 36 hours per week. Appointment is for two years with a possible extension . Your salary is based on your education and experience and is a maximum of € 4,707,- gross per month for a full time position (scale 10 in the Collective Labour Agreement for University Hospitals).

LUMC

At the Leiden University Medical Center, we continuously work on improving patient care. We invest in groundbreaking, international research and work with the latest equipment. Together with our team of doctors, medical specialists, teachers, academic researchers and supporting staff, we aim for the best quality in health care, education and international research. And we need you to realize our goals!

Department of Cell and Chemical Biology

Within the Department of Cell and Chemical Biology, a team of professionals investigates functional regulation of proteins by post-translational modifications including SUMOylation, ubiquitylation and phosphorylation. This enables us to improve our knowledge about fundamental processes of life at the molecular level and to improve our knowledge about disease-linked de-regulation of these processes. Our research group belongs to the LUMC profile area Cancer Pathogenesis & Therapy. The department is a member of the Medical Genetic Center South-West Netherlands (MGC) research school.