Genetically engineered T cells are a prominent addition to the oncologist’s toolbox. CAR T cells are one example that is already widely used to treat hematological malignancies. Growing insights into the genetic programs that promote or limit T cell function open-up exciting possibilities to genetically empower T cells used for adoptive therapies against cancer, but also to treat autoimmune diseases and protect transplanted organs. 

We are looking for an ambitious postdoctoral fellow!

Project
In this project, we will develop high efficiency precision editing technology in T cells that avoids untoward damage to the genome, achieves defined expression characteristics and allows introduction of point mutations. These methods will be used for the generation of new therapeutic T cell products (in collaboration with hematologists of the Amsterdam UMC) as well as for basic research in which the candidate can also assume a vital role.

We are looking for an ambitious postdoctoral fellow with a strong background in molecular biology, preferably with experience in gene editing. 

Fixed-term contract: 3 years.

We offer 3 years of funding in a vibrant international multidisciplinary scientific environment.

Dr. Derk Amsen and Dr. Monika Wolkers have a longstanding interest in the molecular regulation of T-cell function (117; Nature Immunol. 2018,19:538; Nature Immunol. 2018 19, 828; Immunity 2018,5:1046; Nature Immunol. 2016,17:1467; Nature Immunol. 2014,15:1143; Immunity 2007,27:89; Cell 2004,117:515; Science 2004, 304:1314).

Successful applicants will be embedded in a strong and collaborative community studying T cells (25+ students and postdocs).  We take pride in developing our postdocs and students through intra/extramural education and enthusiastically provide proven effective mentoring for the acquisition of personal grants (Veni, Vidi, Vici, LSBR, KWF, ERC) and further career development.

• salary and conditions are conform CAO Sanquin;
• 8,33% end-of-year bonus; i.e. a thirteenth month in case of full-year employment;
• partial reimbursement of travel costs;
• a pension plan with Pensioenfonds Zorg & Welzijn (PFZW);
• at fulltime employment (36 hours) 201 hours of leave per annum.

Sanquin

The mission of Sanquin is: “Together with the donor we ensure a better life for patients”.
Sanquin is a knowledge-driven not-for-profit organization that supplies life-saving products and services, as well as involved in blood transfusion medicine- and immunology- related research. The research is performed by a dedicated staff and it is focused around four research themes: 1. Anemia, 2. Bleeding and Hemostasis, 3. Inflammation and immunity, 4. Immune therapy.