You will join our research line focusing on the value of non- (or minimally) invasive biomarkers in the diagnosis and prediction of acute rejection after kidney transplantation. Markers of interest include (in addition to clinical characteristics) donor-derived cell-free DNA, protein profiles (proteomics) and urinary chemokines. Acute rejection of a kidney transplant occurs in up to 20% of patients and is associated with poor transplantation outcome. A kidney biopsy is the gold standard to diagnose rejection, though a biopsy is an invasive procedure and puts patients at risk for procedure-related complications. Therefore one of the priorities in the transplantation field is the identification of non- (or minimally) invasive biomarkers capable to supplement (or even replace) the histopathological score.

You will combine available datasets to search for an optimal combination of parameters in the identification and prediction of rejection. Identified biomarkers will be measured in available material from kidney transplant recipients. An additional question is whether these biomarkers could guide anti-rejection treatment as well as monitor response to anti-rejection treatment. Timely and optimal treatment is necessary to prevent further graft damage and improve both patient and graft survival.

You are an enthusiastic life scientist with good bioinformatic and biostatical skills. Knowledge of computational methods and 'big data' analysis (genomics/proteomics) is preferable. Suitable candidates will have a master degree in biology, biomedical sciences, life sciences, or a related discipline. You are highly motivated, dedicated, independent and capable of working in a multidisciplinary environment.

• You will receive a temporary position for 3 years.
• The gross monthly salary is € 2.631,- in the 1st year and increases to € 3.188,- in the 3th year (scale OIO).
• Excellent fringe benefits, such as a 13th month that is already paid out in November and a individual travel expense package.
• Pension insurance with ABP. We take care of approximately 2/3 of the monthly contribution.
• Special benefits, such as a incompany physiotherapist and bicycle repairer. And there is also a gym where you can work on your fitness after work.

The terms of employment are in accordance with the Collective Labour Agreement for University Medical Centers (CAO UMC).

Erasmus MC

The Erasmus MC is one of the largest kidney transplantation centers in Europe, where annually ~150-200 kidney transplantations are performed. The section Nephrology and Transplantation of the Dept. of Internal Medicine is involved in kidney transplant patient care, research and education, and is part of the recently established Erasmus MC Transplant Institute. We offer a dynamic team of 20 employees including postdocs, PhD students and research technicians. Our research focusses on biomarkers, immunological aspects of kidney transplantation and kidney organoids, all with the aim to improve graft survival and patient well-being after kidney transplantation.