The Faculty of Science / the Institute for Biology is looking for a :

PhD candidate, ‘A novel class of anti-inflammatory glucocorticoid drugs’
Vacancy number: 22-741

Key responsibilities
The PhD candidate will work on a project that involves the development of novel glucocorticoid drugs. These drugs are commonly prescribed to treat autoimmune and inflammatory diseases, but their use is limited by their side effects. However, in recent years we have developed a novel glucocorticoid drug that has virtually no side effects, by chemically modifying the glucocorticoid drugs prednisolone and dexamethasone. Thereby, we have created an inactive ‘prodrug’, that is converted into an active compound by an enzyme that is specifically active in inflamed tissue. This PhD project will focus on the mechanism of action of the developed prodrug in more detail, in particular on the tissue- and cell type-specificity of the responsible enzyme and on how its activity is regulated. Zebrafish and cell cultures will be used as model systems. Additionally, based on the validated proof-of-concept, other types of prodrugs will be generated and screened to broaden the scope of the project.

Selection Criteria

• MSc degree in biology, biomedical/biopharmaceutical sciences, life sciences or a related discipline (also candidates close to graduating are encouraged to apply)
• Practical experience in molecular and cellular biology, preferably experience with experimental work using mammalian cell culture and/or zebrafish
• Theoretical knowledge of immunology and pharmacology
• English conversation, writing and presentation skills
• Ability to work in an interdisciplinary collaborative project

Terms and conditions 
We offer a  full-time 1 year term position for initially one year. After a positive evaluation of the progress of the thesis, personal capabilities and compatibility the appointment will be extended by a further three years. Salary range from € 2541 to € 3247 gross per month (pay scale P in accordance with the Collective Labour Agreement for Dutch Universities).

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. Candidates from outside the Netherlands may be eligible for a substantial tax break.

All our PhD students are embedded in the Leiden University Graduate School of Science www.graduateschools.leidenuniv.nl. Our graduate school offers several PhD training courses at three levels: professional courses, skills training and personal effectiveness. In addition, advanced courses to deepen scientific knowledge are offered by the research school.

Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.