Within the TKI-PPP funded project "Click & create" (IXA TKI-PPP: Danielle Vugts - Click & Create - YouTube) we aim to investigate new linker technology for optimized antibody-drug conjugates and antibody-imaging agents. This project is a collaboration between Tracer Center Amsterdam of the department of Radiology & Nuclear Medicine, Prof. dr. Marjolein van Egmond of the department of Molecular Cell Biology and Immunology and the company Cristal Therapeutics.

About your role
We are looking for an excellent and highly motivated postdoctoral fellow biomedical sciences. You will work both at Tracer Center Amsterdam of the department of Radiology & Nuclear Medicine and at the department of Molecular Cell Biology and Immunology. You will work on the development and evaluation of new conjugation technology for antibody-drug conjugates and antibody-imaging agents. You will be in charge of all the in vitro and in vivo analyses. You will work closely together with a research technician, who you will supervise and who will execute the organic chemistry, bioconjugations and radiochemistry.

• A PhD degree in a field related to biomedical sciences, (medical) biology, or biochemistry;
• Affinity for immunology and cancer;
• Experience with working with rodents and an article 9 certificate
• Interest in in vivo tumor models
• Practical experience in working with radioactivity is a plus
• Experience with functional in vitro assays;
• Excellent communication skills in English, both written and verbal.

• A contract for 3 years (the duration of the project).
• Salary range is 3047-4800 euro Gross for full-time employment (depending on education and experience).
• In addition to a good basic salary, you will receive, among other things, 8.3% year-end bonus and 8% vacation allowance. Calculate your net salary here.
• Free and unlimited access to our online learning environment GoodHabitz.
• Pension accrual with ABP, of which we pay 70% of the premium.
• Reimbursement of 75% of your public transport costs. Would you rather travel by bike? Then we have a good bicycle scheme.
• An active staff association and the Young Amsterdam UMC association, both of which organize fun (sports) activities and events.

For more information about our fringe benefits and terms of employment, please visit https://werkenbij.amsterdamumc.org/en .
Applying for a VOG (Certificate of Good Conduct) is mandatory for every new employee. The application for a VOG is started from Amsterdam UMC as soon as the new employee has been appointed.

Amsterdam UMC

The department of Radiology & Nuclear Medicine is, amongst others, specialized in conducting research using nuclear imaging techniques, more specifically Positron Emission Tomography (PET). Our aim is to use PET for diagnosis of disease, treatment monitoring and patient selection. Tracer Center Amsterdam develops the new PET tracers needed in the clinic for neurological diseases as well as oncology, rheumatology and cardiology. The research of TCA focusses on radiochemistry methodology development, selection of biological targets and development of new PET tracers for these targets, preclinical in vivo evaluation of new PET tracers as well as good manufacturing practice (GMP) compliant synthesis of PET tracers. TCA is now located in the Amsterdam UMC Imaging Center that is equipped with a brand new lab for TCA according to current state of the art. At the Imaging Center all imaging modalities are brought together and the synergy between basic research, pre-clinic and clinic will be further enhanced.

TCA collaborates with many national and international research institutes and pharmaceutical companies and is partner in many (inter)nationally funded projects, amongst others, NWO, ZON-MW, IHI, EU and EU Marie Curie program.

The Department of Molecular Cell Biology and Immunology (MCBI) at the Amsterdam UMC (VUmc location) carries out research at an internationally competitive level and offers a stimulating and collegial work environment. The research of the department concentrates on immunological questions in the fields of cancer, neuroimmunology, skin biology, and inflammation. The research focuses on both fundamental questions aimed at unraveling molecular and cellular mechanisms as well as translational research aiming to apply fundamental knowledge to medical questions. MCBI is part of the Amsterdam Immunotherapy Center.