The nanomedicine group (Prof. Dr. Roland Brock) within the department of Medical Biosciences of the Radboud University Medical Center searches for a postdoctoral researcher fort he project "ADRNALIN - Advanced Delivery of RNA Lipid Nanoparticles" that aims to develop lipid nanoparticles for targeted delivery of RNAs (mRNA, antisense RNA, siRNA). Will you join our team of students, PhDs, and postdocs?

In collaboration with three Biotech companies and the university of Twente, you will prepare lipid nanoparticles, functionalize these lipid nanoparticles with peptides and engineered proteins and investigate their targeting characteristics in vitro and in vivo making use of fluorescence microscopy, microfluidic tumor-on-a-chip systems and animal experiments. This project is part of our activities in tumor targeting and targeting of skeletal muscle in myotonic dystrophy. The employment will be for two years (full time). Ideally, you will start May 1st. Other start dates can be negotiated.

As postdoctoral researcher in this project you will:

• Form RNA-lipid nanoparticles using microfluidic techniques.
• Functionalize these nanoparticles with peptide and protein ligands.
• Characterize these nanoparticles with dynamic light scattering.
• Investigate the targeting and delivery activity using tissue culture and microfluidic tumor-on-a-chip system.
• Determine the in vivo biodistribution using xenograft tumor models in mice. The animal experiments will be conducted in the center for animal experimentation of the Radboudumc and are strongly assisted by technical personnel.

You have a PhD degree and/or postdoc experience in the area of oligonucleotide delivery with experience in the formation and characterization of nanoparticles (dynamic light scattering), fluorescence microscopy and also animal experimentation. You have a demonstrated proficiency in the independent planning, execution and analysis of experiments and you work and communicate well in an interdisciplinary team.

Fixed-term contract: 2 years.

Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. And there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At Radboud university medical center, you will be given trust, and you will take the responsibility to handle everything together.

• A gross monthly salary between € 3.230 and € 5.088 (scale 10) based on full-time employment.
• From 1 November 2023 the wages will increase by 4%.
• An annual vacation allowance of 8% and an end-of-year bonus of 8.3%.
• If you work irregular hours, you will receive an allowance.
• As a full-time employee (36 hours per week), you are entitled to approximately 168 vacation hours (over 23 days) per year.
• Radboud university medical center pays 70% of the pension premium. You pay the rest of the premium with your gross salary.
• You get a discount on health insurance as well: you can take advantage of two group health insurance plans. UMC Zorgverzekering and CZ collectief.
• We provide annual courses, both professional and personal.

In addition to our terms of employment, we also offer employees various other attractive facilities, such as childcare and sports facilities. Want to learn more? Take a look at the CAO UMC.

Radboudumc

The Radboudumc is a university medical center with a strong emphasis on translational research. The department of Medical BioSciences joins researchers from Biochemistry, Cell Biology, Immunology, Physiology and Bioinformatics. The project is financed in part through the Public Private Partnership Health-Holland, Topsector Life Sciences&Health for the stimulation of public-private collaborations and is conducted in collaboration with the Biotech companies RIBOPRO (mRNA services), Mercurna (mRNA therapeutics), siTOOLS (siRNA services) and the University of Twente. As postdoc in this project you will be member of a team of researchers (Postdoc, PhD, students) performing research in nanomedicine using microscopy, microfluidic tumor-on-a-chip systems and animal studies.

Radboudumc
Radboud university medical center is a university medical center for patient care, scientific research, and education in Nijmegen. Radboud university medical center strives to be at the forefront of shaping the healthcare of the future. We do this in a person-centered and innovative way, and in close collaboration with our network. We want to have a significant impact on health and healthcare. We want to improve with each passing day, continuously working towards better healthcare, research, and education. And gaining a better understanding of how diseases arise and how we can prevent, treat, and cure them, day in and day out. This way, every patient always receives the best healthcare, now and in the future. Because that is why we do what we do.

Read more about our strategy and what working at Radboud university medical center means. Our colleagues would be happy to tell you about it. #weareradboudumc