Our team studies novel therapeutic modalities in colorectal cancer (CRC) as well as the pathways that dictate tumor formation and metastasis.

Your project aims to study the mechanism that underlies the metastatic process in mesenchymal CRC and addresses how this form of cancer escapes from therapy.

About your role

• Your work involves the use of patient derived organoid cultures, mouse organoid models derived from GEMM and the in vivo models themselves to study the metastatic process and therapeutic modalities.
• Using standard molecular techniques you will modify tumor models to validate mechanisms of resistance and metastasis.
• Using cell biological assays you will study tumor development in vitro and therapy impact in vitro and in vivo.

• You hold a PhD degree or will soon graduate.
• You have experience in cancer research.
• You have practical experience in laboratory sciences
• You have academic skills to drive a project
• You have proven mentoring skills.
• You like to work in a team and collaborate.
• You are pro-active and outgoing.
• You combine curiosity with ambition and practical with theoretical skills.

• We offer a contract for 1 year (12 months) , with the possibility of extension by another 2 years.
• We are open to part-time/job share options.
• Salary scale 10: € 3.230 - € 5.088 gross for full-time employment (depending on education and experience).
• In addition to a good basic salary, you will receive, among other things, 8.3% year-end bonus and 8% vacation allowance. Calculate your net salary here.
• Pension via BeFrank
• Excellent accessibility by public transport and reimbursement of a large part of your travel expenses. We also have sufficient parking spaces at the AMC location and a good bicycle scheme.

Amsterdam UMC

The position is open in the Center of Experimental Molecular Medicine within the Laboratory of Experimental Oncology and Radiobiology. Within this lab a large number of scientists (>70) among which more than 40 PhD students, study cancer biology mainly in gastroenterology. This large team is a dynamic group of highly skilled enthusiastic young scientists who all have strong ambitions to successfully drive their respective projects. The continuous effort to learn and improve makes our department a perfect place for an ambitious young scientist.

The team you will join is the group of Jan Paul Medema, specialized in colorectal cancer subtypes, Cancer Stem Cells and therapy resistances mechanisms.

For more info check Jan Paul Medema - Amsterdam UMC research portal

Cancer Center Amsterdam (amsterdamumc.org)

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