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Do you hold a Master's degree in Neuroscience, Molecular (Neuro)Biology, Biomedical Sciences, Biochemistry, Genetics, or a related field, or are you close to obtaining such a degree? Are you passionate about science and a critical and creative thinker? Are you interested in exploring the molecular mechanisms underlying motor neurodegenerative disease and performing cutting-edge biomedical research? If so, then you have a part to play as a PhD Candidate!
We are recruiting for a PhD candidate to work independently on Drosophila genetics projects. Your main project will involve the characterisation of mutant lines identified in a forward genetic screen for genes required for axonal maintenance (unpublished). These mutants display adult-onset progressive degeneration of peripheral motor and/or sensory neurons. Phenotypic and molecular characterisation of these mutants involves Drosophila genetic approaches, behavioural analysis, immunohistochemistry, fluorescent in situ hybridisation (FISH), in vivo non-canonical amino acid tagging (NCAT), confocal and super-resolution imaging, molecular biology, biochemistry, and next-generation sequencing. In addition, you will have the opportunity to contribute to other ongoing projects in the lab, for instance by studying the molecular pathogenesis of CMT peripheral neuropathy associated with mutations in tRNA synthetases, following up on our recently published work (Zuko, Mallik et al, Science, 2021). You will also have the opportunity to collaborate with a senior postdoctoral researcher and an experienced PhD student who can provide practical/experimental guidance. You will get some exposure to teaching in Master's courses, and you will have the opportunity to collaborate with and supervise Master's students.
Fixed-term contract: You will be employed for an initial period of 18 months, after which your performance will be evaluated. If the evaluation is positive, the contract will be extended by 2.5 years (4 year contract).
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