Human based in vitro test systems are important tools for understanding the mechanistic basis of chemical induced toxicity and to aid in the development of safer chemicals including pharmaceuticals. In this project the candidate will be involved in optimising test methods for kidney and liver testing of chemicals of concern. The project is part of an EU consortium, CHIASMA, which aims to create an integrated framework to perform human and enviromental safety evaluation in a regulatory context.

Your duties

• Culturing and differentiation of human renal and hepatic cell system, including induced pluripotent stem cell (iPSC) derived models
• Toxicological evaluations of applied test compounds including viability assays, barrier function, mitochondrial activity, metabolism and transcriptomics,
• Data analysis, including analytical workflows,
• Conduct research within the scope of the project leading to a dissertation,
• Publish scientific articles and present research results at conferences,
• Supervision of MSc and BSc students,
• Collaborate within the team and with other international researchers.

• Master degree (or equivalent) in Molecular or Cellular biology, Biochemistry, Biomedical Science, (Analytical) Chemistry, Pharmacology, Toxicology, or a related discipline;
• Interest in human in vitro applications and cellular assays
• Good communication, organizational and social skills;
• High proficiency in speaking and writing in the English language;
• Strong motivation for scientific research.

As a university, we strive for equal opportunities for all, recognising that diversity takes many forms. We believe that diversity in all its complexity is invaluable for the quality of our teaching, research and service. We are always looking for talent with diverse backgrounds and experiences. This also means that we are committed to creating an inclusive community so that we can use diversity as an asset.

We realise that each individual brings a unique set of skills, expertise and mindset. Therefore we are happy to invite anyone who recognises themselves in the profile to apply, even if you do not meet all the requirements.

Fixed-term contract: 1 year.

A challenging position in a socially engaged organisation. At VU Amsterdam, you contribute to education, research and service for a better world. And that is valuable. So in return for your efforts, we offer you:

• a salary of minimum € 2.872,00 (PhD) and maximum € 3.670,00 (PhD) gross per month, on a full-time basis. This is based on UFO profile PhD candidate. The exact salary depends on your education and experience.
• a position for at least 0.8 FTE. Your employment contract will initially last 1 year. Afterwards, the possibility of expansion exists.

We also offer you attractive fringe benefits and regulations. Some examples:

• A full-time 38-hour working week comes with a holiday leave entitlement of 232 hours per year. If you choose to work 40 hours, you have 96 extra holiday leave hours on an annual basis. For part-timers, this is calculated pro rata.
• 8% holiday allowance and 8.3% end-of-year bonus
• solid pension scheme (ABP)
• contribution to commuting expenses
• optional model for designing a personalized benefits package

Vrije Universiteit Amsterdam

Division of Molecular Toxicology
At the division of Molecular Toxicology, dept of Chemistry and Pharmaceutical Sciences research is carried out to study the molecular mechanisms underlying the toxic effects of drugs and other chemicals. Using innovative human based cellular model systems, cellular assays and metabolomics the mechanism by which chemicals can cause adverse effects are investigated and elaborated.

Faculty of Science
Researchers and students at VU Amsterdam’s Faculty of Science tackle fundamental and complex scientific problems to help pave the way for a sustainable and healthy future. From forest fires to big data, from obesity to malnutrition, and from molecules to the moon: we cover the full spectrum of the natural sciences. Our teaching and research have a strong experimentally technical, computational and interdisciplinary nature.

We work on new solutions guided by value-driven, interdisciplinary methodologies. We are committed to research, valorisation and training socially engaged citizens of the world who will make valuable contributions to a sustainable, healthy future.

Are you interested in joining the Faculty of Science? You will join undergraduate students, PhD candidates and researchers at the biggest sciences faculty in the Netherlands. You will combine a professional focus with a broad view of the world. We are proud of our collegial working climate, characterised by committed staff, a pragmatic attitude and engagement in the larger whole. The faculty is home to over 11,000 students enrolled in 40 study programmes. It employs over 1,600 professionals spread across 10 academic departments.

Vrije Universiteit Amsterdam
Vrije Universiteit Amsterdam stands for values-driven education and research. We are open-minded experts with the ability to think freely. - a broader mind. Maintaining an entrepreneurial perspective and concentrating on diversity, significance and humanity, we work on sustainable solutions with social impact. By joining forces, across the boundaries of disciplines, we work towards a better world for people and planet. Together we create a safe and respectful working and study climate, and an inspiring environment for education and research. Learn more about our codes of conduct

We are located on one physical campus, in the heart of Amsterdam's Zuidas business district, with excellent location and accessibility. Over 6,150 staff work at the VU and over 31,000 students attend academic education.

Diversity
Diversity is the driving force of the VU. The VU wants to be accessible and receptive to diversity in disciplines, cultures, ideas, nationalities, beliefs, preferences and worldviews. We believe that trust, respect, interest and differences lead to new insights and innovation, to sharpness and clarity, to excellence and a broader understanding.

We stand for an inclusive community and believe that diversity and internationalisation contribute to the quality of education, research and our services.

Therefore, we are always searching for people whose backgrounds and experience contribute to the diversity of the VU community.