Lipid metabolism is tightly regulated both at the cellular as well as whole-organism level. This regulation ensures that the level of lipids does not increase to toxic levels and that they are available at sufficient amounts for processes requiring them. Disruption of this balance is at the center of several pathological conditions in humans, most notably fatty liver and cardiovascular disease.

 Our group is broadly interested in the transcriptional and post-transcriptional regulation of lipid and energy metabolism (e.g Zelcer et al., Science 2009; Zelcer et al. MCB 2014; Sharpe et al. TIBS 2014; Loregger et al. MCB 2015; Nelson et al. Circ Res 2016; Loregger et al. ATVB 2017; van Loon et al. ATVB 2018). Using functional genetic approaches we have recently identified several novel genes which play a previously unrecognized role in key lipid-dependent cellular processes. As such, the central goal of this VICI-supported project is to elucidate the role of these genes in lipid metabolism in vitro at the mechanistic and cellular level (using e.g. RNAseq, metabolomics, mass spectrometry, functional assays), as well as to evaluate their contribution to development of metabolic disease in vivo in mice.

As part of this VICI project we have developed several new conditional mouse models of the identified genes that are implicated in lipid and energy metabolism. We are looking for a highly-motivated scientist with a PhD in Medical Biology, Life Sciences, Biochemistry or a related field with a proven track record and affinity for conducting (metabolic) studies in mice. Experience with animal experiments and holding an article 9 certificate (or equivalent animal handling diploma) is an advantage. The candidate should have good command of oral and written English. Excellent communication skills and the ability to work within an international research group are essential.

We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at AMR means working in an inspiring and professional environment where development is encouraged in every respect.

• The minimum gross monthly salary is €2.659,- and the maximum gross monthly salary is €4.216,- based on a 36-hour work week is commensurate with qualifications and experience. (scale10 CAO UMC) 
• The base salary does not include holiday pay (8%) and a year-end bonus (8.3%).
• We offer a fulltime position for a period of 2 years, with ample possibility for extension.
• In addition to the salary, monthly savings are made for the Personal Budget (at least 1.55% of the salary) that you can use for training or personal development.
• In addition to excellent accessibility by public transport, AMC also has a sufficient number of parking spaces for employees.
• Pension is accrued at Be Frank.

For an overview of all our other terms of employment, see http://www.werkenbijamc.nl/arbeidsvoorwaarden-amr

AMC Medical Research

The AMC is more than just a hospital. It is a world in which patient care, research and education are integrated, and in which people are always central. It is an academic world full of possibilities for talented individuals that are looking for a place where they can excel. Thinking big, daring to dream, cooperating internationally. And never letting yourself be put off by ‘It’s not possible’ or ’It won’t work anyway’. That is the AMC mentality.

http://www.amc.nl/

The Zelcer group is located in the Department of Medical Biochemistry. Additional information on our research and group can be found on our website: http://www.zelcerlab.eu/