PhD/ Postdoc in Bioinformatics on “Single cell sequencing and analysis for cancer biology

The Chien Lab is looking for a self-motivated PhD or postdoc with a strong background in computational biology to study (single cell) cancer genomics, epigenomics and transcriptomics. We develop tools combining advanced imaging & analysis as well as single cell sequencing and proteomic profiling technologies to address biological questions, particularly in cancer biology.

The goal of the project is to investigate underlying molecular mechanisms of rare & aggressive subpopulations of cancer cells that are responsible for tumor metastasis, recurrence and therapy resistance. The candidate will drive the (single cell) multi-omics analysis efforts of the lab, including (epi)genomics, transcriptomics and proteomics) and identify therapeutic targets (biomarkers or druggable targets) via integrated analysis using different (machine learning-based) models or methods. The candidate will also be involved in a project, aiming to decipher cell lineages of aggressive subpopulations of cancer cells using phylogenetic inference analysis (from single cell data). The successful candidate will also be part of Oncode Institute, which Dr. Chien is affiliated with.

The gross monthly salary amounts a maximum of € 4.800,- (scale 10), depending on your level of education and relevant experience and based on a full-time working week of 36 hours. The terms of employment are in accordance with the Collective Bargaining Agreement for University Medical Centers (CAO UMC).

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