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We are looking to an ourstanding experimentalist for this exciting NWO-funded project at the interface of biochemistry and biophysics that has as its goals to understand the dynamics of eukaryotic DNA replication.
What are you going to do?
In this fully-funded project, you will:
About the project
During our lifetimes, we copy approximately a lightyear’s worth of DNA, and how the different components of the molecular machinery (the replisome) work together to achieve this successfully is an area of highly active research. Here, you will take on the exciting challenge of understanding the dynamics of DNA replication by purifying, reconstituting, and studying the activity of eukaryotic replisome at the single-molecule level. You will examine replisome composition, replisome motion dynamics, and the interplay between these two quantities; and examine how these change in the context of chromatin or obstacles on the DNA. To do so, you will employ a combination of biochemical approaches (protein purification, biochemical assays, DNA sequencing) and novel biophysical instrumentation (e.g. fluorescence imaging, single-molecule force spectroscopy, microfluidics, cryo-electron microscopy). You will analyze the resulting datasets using biophysical modelling, interact with collaborators in molecular biology and biochemistry in the United Kingdom (involving extensive visits), and in doing so, publish high-quality scientific papers to advance this exciting field.
For this innovative, interdisciplinary, and NWO-funded project, we are looking a quantitative biochemist, with:
We look for friendly and driven colleagues of all kinds to enrich our team. We would like to welcome our new colleague as soon as possible in 2023.
Fixed-term contract: 4 years.
TU Delft offers PhD-candidates a 4-year contract, with an official go/no go progress assessment after one year. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities, increasing from € 2541 per month in the first year to € 3247 in the fourth year. As a PhD candidate you will be enrolled in the TU Delft Graduate School. The TU Delft Graduate School provides an inspiring research environment with an excellent team of supervisors, academic staff and a mentor. The Doctoral Education Programme is aimed at developing your transferable, discipline-related and research skills.
The TU Delft offers a customisable compensation package, discounts on health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. For international applicants we offer the Coming to Delft Service and Partner Career Advice to assist you with your relocation.
Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context. At TU Delft we embrace diversity and aim to be as inclusive as possible (see our Code of Conduct). Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale.
Challenge. Change. Impact!
Faculty of Applied Sciences
With more than 1,000 employees, including 135 pioneering principal investigators, as well as a population of about 3,400 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. To that end, we train students in broad Bachelor's and specialist Master's programmes with a strong research component. Our scientists conduct ground-breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics. We are also training the next generation of high school teachers and science communicators.
Click here to go to the website of the Faculty of Applied Sciences.
The Department of Bionanoscience focuses on the fundamental understanding of biological processes, from the level of single molecules to the full complexity of living cells. This research provides fascinating insight in the molecular mechanisms that lead to cellular function. Furthermore it enables the in vitro bottom-up construction of cellular machinery and it impacts applications ranging from biomolecular diagnostics to novel antibiotics and targeted nanomedicine. The department features a strongly multidisciplinary and international team of scientists, whose research areas include single-molecule biophysics, synthetic biology, as well as (quantitative) cell biology.
Delft University of Technology (TU Delft)
Mekelweg 2, 2628 CD, Delft
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