Every time a cell divides it faces the formidable task of copying the 3 billion bases of our genome. The replication machinery faces many hurdles during this process. DNA damage is one of these hurdles, however, it turns out that the DNA molecule itself can form alternative structures that also form prevalent roadblocks for the DNA replication machinery. These structures can cause genome instability when not properly regulated and have been linked to neurodegenerative diseases and cancer. In this project we will use a powerful biochemical system, the Xenopus egg extract system, to define mechanisms that resolve these non-canonical DNA structures to maintain genome integrity. The PhD student will work in a highly collaborative and ambitious environment, with access to top-class facilities.

We are looking for a highly motivated and independent scientist, who thrives in a collaborative and international environment. A background in protein biochemistry or molecular biology is an advantage, but not an absolute requirement. The candidate should have an MSc degree and excellent communication skills in English.

Fixed-term contract: 1 year.

Depending on education and experience the minimum salary is € 2.770,- and the maximum salary is € 3.539,- gross per month for a full-time appointment (scale P cao Nederlandse Universiteiten/KNAW). This is exclusive of 8% vacation allowance, 8.3% year-end bonus, travel allowance, internet allowance, home working allowance and pension accrual with ABP.

The KNAW offers its staff an excellent package of secondary benefits. A package that meets the different needs of employees depending on their stage of life, lifestyle or career ambitions. For example, by working an extra two hours a week, it is possible to increase the number of days off from 29 to 41 days a year (with full-time employment).

For a complete overview of the terms of employment, please refer to the web page: werken bij de KNAW.

Applying for a Certificate of Good Conduct can be part of the employment procedure.

Hubrecht Institute

The Hubrecht Institute is a research institute focusing on developmental and stem cell biology. At the institute, more than 20 research groups perform fundamental and multidisciplinary research, both in healthy systems and disease models. The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW) and is located on the Utrecht Science Park 'De Uithof'. Since 2008, the institute has been affiliated with the University Medical Center Utrecht, advancing the translation of research into clinical practice. The Hubrecht Institute has a partnership with the European Molecular Biology Laboratory (EMBL).

Diversity & Inclusion
The KNAW considers a working environment in which everyone feels welcome and appreciated of great importance. A working environment in which attention is paid to individual quality and where development opportunities are paramount. Together we strive for an inclusive culture in which we embrace differences. We would therefore like to invite candidates who want to contribute to this through their background and experience. In the event of equal suitability, preference will be given to the candidate who thus enhances diversity within the Academy.

We will not respond to any supplier enquiries based on this job advertisement.