Postdoctoral Researcher in RNA Biology and Epitranscriptomics

Are you fascinated by RNA biology and mRNA modifications? And do you believe in the power of omics technologies to study how mRNA modifications regulate gene expression and cell fate? If so, then this may be the job for you! Supported by a NWO-VICI grant, we are looking for a Postdoctoral Researcher to help further our understanding of the role of mRNA modifications in normal and perturbed blood cell differentiation.

We are looking for an ambitious postdoctoral researcher with ample experience in molecular biology and/or protein biochemistry. Experience with RNA biology and methods to profile mRNA modifications are a plus, but are not strictly required. As a postdoctoral researcher, you will participate in a NWO-VICI project (a team currently consisting of two PhD candidates) dedicated to studying the epitranscriptome, and more specifically, the role of mRNA modifications and their 'readers' in (perturbed) blood cell differentiation. You will also collaborate with other lab members in ongoing proteomics-based projects. Furthermore, you will have the opportunity to develop novel ideas and work on additional independent projects that align with this research theme.

• You hold a PhD in molecular biology, analytical chemistry or a related field.
• You have excellent communication and writing skills (in English).
• You possess strong analytical skills and have a result-oriented attitude.
• You have creative thinking skills and a high degree of independence.

• Experience with RNA biology and associated methods (i.e. PAR-CLIP, m6A profiling, etc).
• Experience with mammalian cell culturing.
• Experience with bioinformatics analysis of large (proteomics, genomics, and transcriptomics) datasets.
• Experience with state-of-the-art interaction proteomics and genomics applications.

• It concerns an employment for 0.8 - 1.0 FTE.
• The gross monthly salary amounts to a minimum of €3,226 and a maximum of €5,090 based on a 38-hour working week, depending on previous education and number of years of relevant work experience (salary scale 10).
• You will receive 8% holiday allowance and 8.3% end-of-year bonus.
• You will be employed for an initial period of 2 years, with option for extension.
• You will be able to use our Dual Career and Family Care Services. Our Dual Career and Family Care Officer can assist you with family-related support, help your partner or spouse prepare for the local labour market, provide customized support in their search for employment and help your family settle in Nijmegen.
• Working for us means getting extra days off. In case of full-time employment, you can choose between 30 or 41 days of annual leave instead of the legally allotted 20.

This project will be carried out at the Department of Molecular Biology. The research in Michiel Vermeulen's team currently focuses on understanding how genes are regulated and expressed in stem cells and cancer.

The department of Molecular Biology is part of the Radboud Institute for Molecular Life Sciences (RIMLS-Science), which is one of the six research institutes of the Faculty of Science of Radboud University. The overarching aim of RIMLS-Science is to decipher molecular mechanisms of disease. Research areas of RIMLS-Science include epigenetics, stem-cell and developmental biology, and computational biology. The central research theme is regulation of gene expression during development and in health and disease. Important tools used at the institute include next-generation sequencing, mass spectrometry, single-cell multi-omics analysis and computational analysis and method development. To perform state-of-the-art research, RIMLS-Science operates its own wet lab and computational facilities. RIMLS-Science actively contributes to teaching activities in the Biology study programme at Radboud University. Michiel Vermeulen's lab consists of about 15 researchers and provides a vivid, international research environment. The extensive collaborative network (i.e. the Oncode Institute and the Radboud university medical center) also provides ample opportunities for networking and joint research activities both within the Netherlands and abroad.