Research Technician Chaudhuri/Taneja lab

The Taneja Lab and Ray Chaudhuri Lab are seeking a motivated research technician to investigate how chromatin remodeling safeguards replication forks under stress, a key process for overcoming chemoresistance and improving patient outcomes. This research involves patient-derived cell lines, mouse tumor models, and clinical biopsy samples to uncover fundamental mechanisms and develop novel strategies to enhance cancer therapies.

The selected candidate will perform experiments and receive training in an innovative technology developed in our lab for isolating single-molecule chromatin fibers from various tumor models, including solid and liquid biopsies. The role requires proficiency in confocal imaging and molecular cloning, along with maintaining and culturing cells in tissue culture systems. The candidate will also work with CRISPR-based models to perform genetic modifications, prepare laboratory reagents, maintain equipment and inventory, and analyze data using basic statistical methods.

As the research progresses, the technician will take on increasingly complex experimental tasks with greater independence. We seek a detail-oriented individual with strong organizational skills and a keen interest in learning cutting-edge techniques in chromatin and cancer research.

The technical research assistant will work under supervision to support PhD students and post-docs. One main task will be the management of growing mouse colonies.

Experience with techniques in molecular biology and cell biology is required. We are seeking enthusiastic, self-motivated individuals who thrive in a fast-paced, challenging research environment, and can interact well with others as part of a cohesive team. The ideal candidate will have the following skills: experience with pre-clinical samples is preferable, preferentially also DNA cloning, transfections and infections; cell based assays including maintenance of cells; PCR/RT-PCR and other biochemical techniques;. Optimally the candidate has experience with flow cytometry and sorting.

Being able to present a certificate of good conduct, a valid proof of identity, diploma's and/ or relevant registration such as BIG/ RGS are conditions for the appointment.

Erasmus MC stands for a healthy population and excellence in healthcare. By conducting groundbreaking work, we aim to push boundaries through leading the way in research, education and healthcare. We have access to the latest equipment and techniques in a state-of-the-art environment.

The department of Molecular Genetics houses innovative technologies and top level facilities to support its research programs, and is embedded in the dynamic, internationally competitive research community of over 40 biomedical research labs within the Erasmus MC.