PhD candidate 'Pancreatic ductal adenocarcinoma'

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancer types, with a very poor survival rate. In this ERC-funded PhD project, you will work at the forefront of translational cancer research to develop novel targeted therapeutics aimed at modulating the tumor stroma and improving the efficacy of chemo-immunotherapy in PDAC. You will explore innovative strategies using peptide-based therapeutics and nanomedicine approaches.

A hallmark of PDAC is its abundant and complex tumor stroma, which not only supports tumor progression but also forms a major barrier to effective treatment. Conventional therapies, including chemotherapy and even the most advanced immunotherapies, have shown limited clinical benefit for many patients.

This position offers a unique opportunity to contribute to impactful research that may ultimately improve outcomes for patients with pancreatic cancer.

As a PhD candidate, you will:

• Design and conduct experimental studies on stromal biology in PDAC.
• Develop and test peptide- and nano-based targeted therapeutic strategies.
• Work with in vitro and in vivo PDAC models.
• Analyze and interpret experimental data and present findings at meetings and conferences.
• Contribute to scientific publications and your PhD thesis.
• Collaborate closely with multidisciplinary team members, including biologists, clinicians, and pharmaceutical scientists.

You are a curious, proactive, and scientifically driven PhD candidate. In addition, you are able to work independently as well as in a team. Strong organizational and communication skills support your daily work, while perseverance and a critical scientific mindset characterize your overall approach.

Key requirements

• Master’s degree in biomedical sciences, pharmaceutical sciences, molecular biology, nanomedicine, or a related field.
• Hands-on experience with cell culture and molecular/biochemical techniques.
• Strong interest in cancer biology and translational research.
• Excellent command of English (written and spoken).

Preferred

• Experience with animal models, peptide design, or drug delivery systems.
• Experience in nanomedicine or biomaterials.

At Radboud university medical center, you build on your future. We are committed to providing the best care, education, and research. And we are true to our word, because we help you develop and seize opportunities and give you the room to grow. As an employer, we believe that employees should feel vital and happy at work in all stages of life. We are also committed to creating a healthy and safe working environment. Our employment conditions contribute to that. What we offer:

• Upon commencement of employment, you will start at scale 10A, step 0 (€ 3.108 based on a full-time appointment). Over a maximum period of 4 years, you will progress to scale 10A, step 3 (€3.939 based on a full-time appointment). You will also receive an 8% holiday allowance, an 8.3% end-of-year bonus, and a 47% to 72% bonus for working unsocial hours.
• 176 vacation hours per year based on a 36-hour working week.

You will be embedded in a dynamic and international research group at Department of Medical Biosciences, Radboud university medical center (Radboudumc) in Nijmegen, a leading center for patient care, biomedical research, and education. The hosting department has strong expertise in cancer biology, translational oncology, and drug development, and provides access to state-of-the-art facilities and core platforms.

You will work in a collaborative environment where basic scientists and clinicians closely interact, enabling real translational impact. The team consists of motivated PhD candidates, postdocs, technicians, and clinician-scientists who support each other’s development and success.

Radboudumc
Welcome to Radboud university medical center (Radboudumc), where scientific breakthroughs are born through the curiosity and passion of our collaborating researchers in a vibrant environment. We believe trust and excitement are crucial elements to achieving our goals, and we approach our research as teams and with the utmost rigor to make a significant impact on health and healthcare. Our researchers are driven by their fascination with the biological, psychological, and sociological mechanisms underlying health and healthcare. They collaborate with partners from all over the world to improve health outcomes for all. Radboudumc unites patient care, research, education, and corporate learning, which allows us to approach our mission to shape the health and healthcare of the future in an innovative and person-centered way.

Our ambition is to lead the way in the pursuit of prevention, sustainability, meaningful care. We believe that through our research, we can significantly improve the health and well-being of society. Join us on our mission to make a difference in healthcare. Become a part of our community of gifted researchers, professionals or patient partners who are dedicated to making a real impact on population health and healthcare.

Read what it is like to do a PhD at the Radboud University Medical Center.

Any questions? Or wondering what it is like to work at Radboudumc? Then send an email to Jai Prakash, PhD. Use the Apply button to submit your application.