The new approach consists of a novel technique that measures plasma concentrations of about three hundred proteins by means of mass spectrometry. The measurements will create the possibility to develop a ‘plasma protein fingerprint’ related to the risk of these complications. This will be performed in collaboration with the University of Victoria, Canada. You will first develop this ‘plasma protein fingerprint’ (pmid 28895300, 29296750) in the BLEED study (pmid 27935941), and subsequently validate the results in the MAS-study from Italy. The final goal will be to improve identification of patients at high risk for major bleeding and thromboembolism which will eventually lead to optimal prevention. You work includes coordinating measurements, obtaining proteomics data, and performing advanced bioinformatic analyses.

You have a master’s degree and background in (bio)medical, (bio)pharmaceutical and/or bioinformatics. Experience with (epidemiological) research, proteomics or use of R is advantageous, or you have an interest to develop in these fields. Furthermore, you have an interest in working in a multidisciplinary environment and possess solid communication skills.

Fixed-term contract: min. 3 years.

You will be employed on the basis of a 36-hour week. Appointment is for a maximum of four years, to be completed with a doctoral thesis. Your salary is € 2,422 gross per month in the first year, amounting to € 3,103 (scale PhD students, CLA UMC).

Leiden University Medical Center (LUMC)

At the Leiden University Medical Center, we continuously work on improving patient care. We invest in groundbreaking, international research and work with the latest equipment. Together with our team of doctors, medical specialists, teachers, academic researchers and supporting staff, we aim for the best quality in health care, education and international research. And we need you to realize our goals!

Department of Clinical Epidemiology

You will be appointed at the Department of Clinical Epidemiology in the LUMC, which is a research department where clinicians (physicians, pharmacists) work together with epidemiologists and statisticians to understand the etiology of disease, and to optimize patient care and research methodology. You will work with the Center for Proteomics and Metabolomics, a technology focused department equipped with top-end mass spectrometers where advanced bioinformatic methods for data analysis and interpretation are used. The other collaboration will be with the section of Thrombosis and Haemostasis (Department of Internal Medicine) that has a long-standing research line into optimal use of anticoagulants. The study is financed by the ‘Trombosestichting Nederland’.