Radboudumc departments of Human Genetics
closely collaborate in the laboratory of tumor genetics (LTG), that consists of 9 laboratory specialists, 40 technicians and has a close collaboration with the PI groups of Richarda de Voer and Marjolijn Ligtenberg with currently 10 PhD students. LTG provides clinical molecular diagnostics, both somatic and germline, for diagnostic and predictive purposes.
The department of Human Genetics consists of a diagnostics, research and clinical division. Within the diagnostics division (135 FTE) the bioinformatics group (15 FTE) is responsible for developing and maintaining bioinformatics workflows for the analysis of exome, genome and long-read sequencing data. Within this group, currently two bioinformaticians are dedicated to the development and implementation of novel analyses for tumor diagnostic applications. This includes the analysis of TSO500, WES on tumor tissue and of WGS and targeted panels for liquid biopsies.
The bioinformatics group offers access to a complete development setup, based on the Atlassian stack and Java. In addition, there is a large knowledge base on exome and genome analysis, statistics methodology, R, Python, Java, machine learning and other bioinformatic related topics. The development of novel analyses methods is conducted on a high-performance compute environment (>600 cores, 2.5Pb storage) that supports large-scale genome analyses and the setup of diagnostic workflows.
The LTG and the bioinformatics group collaborate with the Radboud Genome Technology Center Genomics for applying novel sequencing technologies in tumor diagnostics. CGAL hosts the latest genome technologies such as exome and genome, TSO500 and Molecular inversion probe (MIPs) technology through Illumina NextSeq 500 or NovaSeq, long-read sequencing through PacBio Sequel IIe instruments. In addition, the laboratory hosts a Bionano Saphyr instrument for the detection of complex structural genome variation.Radboudumc
Radboud university medical center is a university medical center for patient care, scientific research, and education in Nijmegen. Radboud university medical center strives to be at the forefront of shaping the healthcare of the future. We do this in a person-centered and innovative way, and in close collaboration with our network. We want to have a significant impact on healthcare. We want to improve with each passing day, continuously working towards better healthcare, research, and education. And gaining a better understanding of how diseases arise and how we can prevent, treat, and cure them, day in and day out. This way, every patient always receives the best healthcare, now and in the future. Because that is why we do what we do.
Read more about our strategy
and what working at Radboud university medical center
means. Our colleagues
would be happy to tell you about it. #weareradboudumc