We are looking for a highly motivated postdoc to study the role of the BMP and WNT pathways in the context of embryonic development, pediatric sarcoma initiation and progression, and/or tissue regeneration. The ideal candidate has advanced knowledge in signaling transduction of developmental signaling pathways and is interested in combining protein/antibody engineering, cell biology, oncology, and organoid technology. The open position is within the Janda group, which has a long-standing interest in studying the structure-function relationship of ligand-receptor interactions of signaling pathways critically involved in embryonic development and regeneration, and the engineering of signaling modulators to interrogate underlying principles of signaling transduction. Furthermore, we interrogate the initiation and progression of pediatric osteosarcoma and develop novel therapeutic strategies for treating children with metastatic osteosarcoma. The postdoc will have the opportunity to expand on ongoing projects with various international collaborators and initiate new, innovative projects.  

Your qualifications

• PhD with a strong background in cell biology, biochemistry, or related disciplines.
• High level of motivation, curiosity, dedication and responsibility.
• Demonstrated scientific productivity, as evidenced by a strong publication record in top tier journals. 
• Advanced experience in studying the structure-function relationship of ligand-receptor interactions and signal transduction is required.
• Experience in protein biochemistry and protein engineering is a plus.
• Strong motivation, attention to detail, flexibility, and the ability to work within a multi-disciplinary environment is critical.
• Excellent English writing and verbal communication skills are required.

Fixed-term contract: One year, with the intention to extend.

We offer

• We offer a full-time position (based on 36 hours a week) in a very stimulating and interactive research environment. You will also have the opportunity to actively collaborate with various research groups at the Princess Máxima Center. 
• The contract will be initially for one year, with the intention to extend.  
• Your gross monthly salary will be based on your experience and background and will include 8,33% holiday allowance and 8,33 % end-of-year bonus. 
• The Princess Máxima Center operates according to the collective labor agreement ‘CAO ziekenhuizen’.

Princess Máxima Center for Pediatric Oncology

The Princess Máxima Center for Pediatric Oncology is a comprehensive cancer center integrating research with care for all children with cancer in the Netherlands. It is the world’s only single national pediatric cancer center and Europe’s largest. Its aim is to cure every child with cancer and with optimal quality of life. Research at the Máxima is multidisciplinary, covering the complete spectrum from fundamental science to clinical research, all highly integrated. The current 36 research groups work closely with each other and with the clinical staff, all supported by excellent facilities.