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The process of protein glycosylation regulates many biochemical properties and molecular functions, but these versatile biomolecules are currently not well understood. As a PhD Candidate, you will unravel the mechanisms behind protein glycosylation in the cell. You will ultimately contribute to understanding the role of glycosylation in serious diseases like cancer, inflammation or autoimmunity disorders.
Sugar molecules such as glucose not only provide the energy that virtually drives all biological processes, they are also essential molecular building blocks used by all living cells for the glycosylation of proteins and lipids. During glycosylation, about 200 glycosyltransferase enzymes assemble different sugar building blocks into structures called glycans that display a staggering structural diversity. Glycans are attached to glycoproteins and glycolipids and regulate many of their biochemical properties and molecular functions, thereby contributing to proper functioning of the cell. On the other hand, deregulation of glycosylation is associated with every major disease. Despite the importance of these versatile biomolecules, many aspects of how protein glycosylation is orchestrated inside the cell are not well understood.
The Biomolecular Chemistry Department is looking for a PhD candidate to unravel mechanisms of protein glycosylation in the cell. As a PhD candidate, you will work on new approaches to probe glycosylation in human cells at the Golgi system and protein level. This includes the development of tools that enable visualization of specific glycosylation steps and analysis of distinct glycoprotein products using molecular biology and biochemistry techniques. These tools will be validated and applied in human cells, including 2D cell cultures and adult stem cell-derived organoids, with genetically engineered glycosylation machineries. Ultimately, these tools will be used to investigate how pathological processes in cancer, inflammation or autoimmunity deregulate protein glycosylation and vice versa how dysregulated protein glycosylation contributes to pathological processes. This research will advance our understanding of the role of glycosylation in these serious diseases and could open up novel therapeutic avenues.
Your education task may be up to 10% of your appointment.Fixed-term contract: you will be appointed for an initial period of 18 months, after which your performance will be evaluated. If the evaluation is positive, the contract will be extended by 2.5 years (4 year contract) or 3.5 years (5 year contract).
Additional employment conditions
Work and science require good employment practices. This is reflected in Radboud University's primary and secondary employment conditions. You can make arrangements for the best possible work-life balance with flexible working hours, various leave arrangements and working from home. You are also able to compose part of your employment conditions yourself, for example, exchange income for extra leave days and receive a reimbursement for your sports subscription. And of course, we offer a good pension plan. You are given plenty of room and responsibility to develop your talents and realise your ambitions. Therefore, we provide various training and development schemes.
The position is available at the Department of Biomolecular Chemistry of the Institute for Molecules and Materials (IMM) located at the Faculty of Science (FNWI). Our research aligns with the Chemistry of Complex Systems research theme of IMM. You will join the new research group of Dr. Christian Büll investigating protein glycosylation inside the living cell to unravel the principles underlying this diverse post-translational modification and to understand its role in pathology at the cellular, organellar, and molecular level.
IMM is a research institute in chemistry and physics that promotes interdisciplinary research. Its mission is to design and create functional molecules and materials to fundamentally understand their behaviour. IMM consists of 24 research groups active in fields ranging from condensed matter physics to organic chemistry and biochemistry. It focuses on fundamental research with an open eye to societal applications and trains the next generation of leaders in science and innovation. You will have the opportunity to interact with researchers at IMM and participate in institute-wide activities.
The Faculty of Science is a complete, student-oriented science faculty where research and teaching are closely intertwined. The faculty aims to be an academic community with an international character where employees from different backgrounds combine their talents with the goal of being a leading science faculty in Europe.
Radboud University
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