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Inbedding
Dit project is onderdeel van het Consortium programma TRACER ( treating hereditary anemias through stem cell research) binnen het door ZonMW gefinancierde translationele onderzoeksprogramma ‘Pluripotent Stem cells for Inherited Diseases and Embryonic Research’ (PSIDER). Hieronder een korte samenvatting van het Tracer programma (in het Engels):The production or function of blood cells is impaired in a plethora of diseases presenting early in life such as congenital anemias that persist over lifetime. Blood transfusion is often the only therapeutic option, and stem cell transplantation the only curative treatment for severe anemias. Unfortunately, a lack of immune-matched cells often hampers these therapies. The multidisciplinary TRACER team aims to employ iPSCs to: 1) study disease mechanisms, 2) generate engraftable hematopoietic stem cells (HSCs), and 3) develop curative therapies. The TRACER project focuses on two different hereditary anemias: Sickle Cell Diseaseand Diamond Blackfan Anemia. We will focus on mechanisms involved in these hereditary anemias, and on the production of mature blood cells and HSCs from gene-corrected iPSCs. Such an advanced stem cell technology project requires in-depth study of the ethical, legal and societal impact of these new technologies on patients, clinicians, policymakers, regulatory bodies, pharmaceutical enterprises and the general public, to ensure that the benefits will reach the patients.
Tasks
As a PhD candidate on this multidisciplinary scientific project, your tasks are to:
The research team
This project is a collaboration between the department of Donor Studies at Sanquin Research and the department of Cell Biology at Erasmus MC. The PhD candidate will be enrolled in the Graduate School of Social Sciencesof Vrije Universiteit Amsterdam with which the department of Donor Studies has a longstanding collaboration. The department of Donor Studies is an internationally recognized center for high-quality blood donor research. Staff at the department consists of about 15 researchers, including 5 PhD students. The Erasmus MC Department of Cell Biology has ~100 researchers, including ~25 PhD students.
Stakeholders (among others )
OSCAR Nederland: https://www.oscarnederland.nl/; https://www.oscarnederland.nl/website-expertise-netwerk-sikkelcelziekte-thalassemie-binnenkort-online/
Fixed-term contract: 4 years.
Salary and employment conditions in accordance with CAO (collective employment agreement) Sanquin;
A temporary appointment for a period of 4 years;
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