The Chien Lab is looking for a self-motivated PhD or postdoc with a strong background in computational biology to study (single cell) cancer genomics, epigenomics and transcriptomics. We develop tools combining advanced imaging & analysis as well as single cell sequencing and proteomic profiling technologies to address biological questions, particularly in cancer biology.

The goal of the project is to investigate underlying molecular mechanisms of rare & aggressive subpopulations of cancer cells that are responsible for tumor metastasis, recurrence and therapy resistance. The candidate will drive the (single cell) multi-omics analysis efforts of the lab, including (epi)genomics, transcriptomics and proteomics) and identify therapeutic targets (biomarkers or druggable targets) via integrated analysis using different (machine learning-based) models or methods. The candidate will also be involved in a project, aiming to decipher cell lineages of aggressive subpopulations of cancer cells using phylogenetic inference analysis (from single cell data). The successful candidate will also be part of Oncode Institute, which Dr. Chien is affiliated with.

• For postdoc: the successful candidate must have a PhD in a relevant discipline (computational biology/bioinformatics/statistics/computer science) with a publication record that reflects individual accomplishment.
• For PhD: the successful candidate must have a MSc in a relevant discipline and experience (computational biology/bioinformatics/statistics/computer science).
• Proficient in at least one of the following programming languages: R, Python, command line language. A command of machine learning techniques is a plus!
• Experience with next-generation (single cell) sequencing data analysis is preferred.
• A strong command of scientific English in speech and writing is essential.

The gross monthly salary amounts a maximum of € 4.800,- (scale 10), depending on your level of education and relevant experience and based on a full-time working week of 36 hours. The terms of employment are in accordance with the Collective Bargaining Agreement for University Medical Centers (CAO UMC).

Erasmus MC

A healthy population and excellence in healthcare through research and education. This is what Erasmus MC stands for. Conducting groundbreaking work, pushing boundaries and leading the way. In research, education, and healthcare. We are practical people with a high level of expertise, working hard to improve and renew the healthcare of today and the public health of tomorrow.