The Storkebaum lab combines Drosophila and mouse genetics to unravel molecular mechanisms underlying motor neurodegenerative and neuromuscular disorders. Our current focus is on Charcot-Marie-Tooth (CMT) peripheral neuropathy associated with mutations in tRNA synthetases and on amyotrophic lateral sclerosis (ALS) associated with mutations in FUS. More broadly, we are interested in the molecular mechanisms underlying axonal degeneration, with a focus on the role of mRNA translation defects. We use a broad spectrum of methods and techniques including a recently developed method for cell-type-specific in vivo labelling of newly synthesised proteins (NCAT), several high-end imaging techniques (confocal and super-resolution microscopy), single-molecule FISH, single-cell/single-nucleus transcriptomics, whole genome sequencing, mouse and Drosophila behavioural analysis, electromyography, histology, immunohistochemistry, molecular biology and biochemistry. Our dynamic and international team currently consists of three postdoctoral researchers, four PhD students and a technical assistant. In addition, we have strong local, national and international collaborations with scientists working on RNA biology and genetics. You will have the opportunity to present your work to various audiences in lab meetings, institutional seminars, and the Molecular Neurobiology Seminar Series (a Donders Institute Event), and to attend international conferences. We attracted substantial external funding, including an ERC consolidator grant, two JPND grants, and grants from the Radala Foundation for ALS Research, the Muscular Dystrophy Association (MDA), AFM, ARSLA, the Dutch ALS Association, Princess Beatrix Muscle Foundation and the Dutch Research Council (NWO). Recently, we published several papers in high-impact journals, including Science (2), Nature Neuroscience (3), Journal of Cell Biology, Nature Communications (5), Acta Neuropathologica (2), and EMBO Journal.
Nijmegen is a vibrant city surrounded by beautiful nature, ideally suited for hiking and sport activities. The Faculty of Science
at Radboud University is an equal opportunity employer, committed to building a culturally diverse intellectual community, and as such encourages applications from women and minorities.
We are keen to meet critical thinkers who want to look closer at what really matters. People who, from their expertise, wish to contribute to a healthy, free world with equal opportunities for all. This ambition unites more than 24,000 students and 5,600 employees at Radboud University and requires even more talent, collaboration and lifelong learning. You have a part to play!