Our team is interested in understanding the molecular mechanisms that drive CD4 T cell differentiation, with a key focus on how RNA translation controls proliferation and fate decisions of T cells. During an immune response, CD4 T cells get activated and differentiate in CD4 T cell helper subsets with specialized functions. This differentiation process lies at the basis of any immune response against infection or vaccination, and any derailed immune responses in cancer and autoimmune diseases. The goal of our research is to identify key molecular networks that govern this fate decision and their link to targetable cell-surface receptors.

In summary, you will use spectral flow cytometry to characterize CD4 T cell differentiation in in vivo mouse models and human lymphoid organoids, and CRISPR-Cas9 gene editing and other molecular approaches to investigate the role of regulation of RNA translation herein. Altogether, you will contribute to advance our fundamental understanding of CD4 T cell differentiation, which is key to rationally improve future design of immunotherapy across various diseases.

·         MSc in biomedical sciences or a related field with an outstanding academic record.

·         Passion for fundamental research at the cellular and molecular level.

·         Candidates with theoretical and practical expertise in one of the following areas are encouraged to apply: immunology, molecular biology, and RNA biology; having an article 9 registration is advantageous.

·         Ability to work independently as well as in a team.

·         A pro-active attitude, outstanding organizational skills and eye for details.

·         Excellent communication skills in English are essential.

Fixed-term contract: 4 years.

·         This is a fully-funded 4-year PhD studentship.

·         You will be given an employment contract for the production of a PhD thesis for the duration of the program with a maximum of four years. The salary amounts to € 2,901 gross per month in the first year, up to a maximum of € 3,677 in the last year with fulltime employment (scale Pro, CLA UMC)

LUMC

At the Leiden University Medical Center, we continuously work on improving patient care. We invest in groundbreaking, international research and work with the latest equipment. Together with our team of doctors, medical specialists, teachers, academic researchers and supporting staff, we aim for the best quality in health care, education and international research. And we need you to realize our goals!

Immunology

Our team is embedded within the department of Immunology at the LUMC, which focuses on improving diagnostics and therapy of immune-related diseases. The LUMC offers state-of-the-art technical facilities. The project will be an excellent opportunity to carry out impactful research and develop a cutting edge,  multidisciplinary skill set.

The LUMC offers internal courses and in-service training to help you with your personal and professional development. You will be encouraged to participate in national and international networks and courses, and will be mentored on good scientific practice and career advice.