Maintaining the integrity of our genome is crucial to prevent genetic diseases such as cancer. Defects in DNA and chromatin replication, or in DNA repair pathways, can cause DNA mutations and hamper genome integrity. In this project we aim to define how chromatin organization is maintained during DNA replication and how chromatin dynamics is regulated during DNA repair. We will use a powerful biochemical system, the Xenopus egg extract system, that recapitulates DNA replication and repair using a physiological mechanism. We will use existing, and develop novel, sequencing-based methods to examine the dynamic behaviour of nucleosomes and other key factors during these processes. This unique combination will provide important insights into the pathways that keep our genome safe. The candidate will work in a highly collaborative and ambitious environment, with access to top-class facilities.

We are looking for a highly motivated and independent scientist, with a collaborative mindset and experience working in an international team. A background in protein biochemistry or bioinformatics is an advantage. The candidate should have an PhD degree and excellent communication skills in English.

Fixed-term contract: 1 year.

Depending on education and experience the minimum salary is € 3.226 and the maximum salary is € 5.090 gross per month for a full-time appointment (scale 10 cao Nederlandse Universiteiten/KNAW). This is exclusive of 8% vacation allowance, 8.3% year-end bonus, travel allowance, internet allowance, home working allowance and pension accrual with ABP.

The KNAW offers its staff an excellent package of secondary benefits. A package that meets the different needs of employees depending on their stage of life, lifestyle or career ambitions. For example, by working an extra two hours a week, it is possible to increase the number of days off from 29 to 41 days a year (with full-time employment).

For a complete overview of the terms of employment, please refer to the web page: werken bij de KNAW.

Applying for a Certificate of Good Conduct can be part of the employment procedure.

Hubrecht Institute

The Hubrecht Institute is a research institute focusing on developmental and stem cell biology. At the institute, more than 20 research groups perform fundamental and multidisciplinary research, both in healthy systems and disease models. The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW) and is located on the Utrecht Science Park 'De Uithof'. Since 2008, the institute has been affiliated with the University Medical Center Utrecht, advancing the translation of research into clinical practice. The Hubrecht Institute has a partnership with the European Molecular Biology Laboratory (EMBL).

The KNAW considers a working environment in which everyone feels welcome and appreciated of great importance. A working environment in which attention is paid to individual quality and where development opportunities are paramount. Together we strive for an inclusive culture in which we embrace differences. We would therefore like to invite candidates who want to contribute to this through their background and experience. In the event of equal suitability, preference will be given to the candidate who thus enhances diversity within the Academy.

We will not respond to any supplier enquiries based on this job advertisement.