In this study, we will focus on the identification of somatic de novo mutations in Semantic Dementia, which is a specific subtype of frontotemporal dementia (ZonMW Memorabel grant 2017). The postdoc will investigate the underlying disease process on DNA, RNA expression and protein level in brains of deceased patients with semantic dementia. For this project, we will study in a multi-omics approach granular cells obtained by laser capture microdissection of the human dentate gyrus. In a bioinformatic analysis of multi-omics data, the postdoc candidate will determine potential candidate proteins relevant for future functional studies

We are seeking an enthusiastic, highly motivated and excellent postdoctoral researcher with:

• Demonstrated track record in basic/translational research, by preference in neuroscience;
• Hands-on experience as a molecular geneticist or cell biologist (RNA/DNASeq, immunohistochemistry);
• Proven track record of (high-impact) publications;
• Excellent communicative skills and a teamplayer;
• Good command of oral and written English. To present your data and collaborate with other scientists.

You are being able to present a certificate of good conduct is a condition for the appointment.

The gross monthly salary amounts a maximum of maximum of € 4.216,- (scale 10), depending on your level of education and relevant experience and based on a full-time working week of 36 hours. The terms of employment are in accordance with the Collective Bargaining Agreement for University Medical Centers (CAO UMC).

Erasmus MC

A healthy population and excellence in healthcare through research and education. This is what Erasmus MC stands for. Conducting groundbreaking work, pushing boundaries and leading the way. In research, education, and healthcare. We are practical people with a high level of expertise, working hard to improve and renew the healthcare of today and the public health of tomorrow.

Research group headed by Prof.dr. John van Swieten: Our research program is embedded in the Alzheimercenter Erasmus MC, and has a long tradition in translational research: from clinic to bench and vice versa. We aim to identify new genetic factors in the different subtypes of frontotemporal dementia, and determine new neuroimaging and fluid biomarkers markers in the earliest stage of FTD. Our research group has strong collaboration with the Department of Clinical Genetics, Human Genotyping Facility of Internal Medicine, Erasmus MC, the Department of Molecular and Cellular Neurobiology VU University, and the Netherlands Brain bank. As one of the leading expert centers in Europe for diagnostics and scientific research in FTD, we furthermore have excellent collaborations with international researchers and clinicians.