Research Technician | Translational Metabolic Laboratory

We are seeking an enthusiastic and motivated all-around Research Technician to join our dynamic and collaborative team. Our mission? To better understand the molecular mechanisms driving dysfunctional sugar metabolism and protein glycosylation in human genetic diseases affecting the muscle and the brain. Are you our new colleague?

Using patient-derived stem cell and knockout cell models and mouse tissues, we apply cutting-edge metabolomics and (glyco)proteomics to dissect disease mechanisms in rare genetic metabolic disorders. Our ultimate goal: translating fundamental insights into better diagnostics and new therapies for patients.

As a key player in our team, your daily activities will include, but are not limited to cell culture, cell-based assays, metabolite extraction from mouse tissues, stable and transient transfections, and cytochemical stainings and microscopy, and possibly targeted mass spectrometry. You will be responsible for designing, planning, and executing your own experiments independently, as well as analyzing and reporting your results and ideas in close collaboration with the group. You will be supporting several projects at once so we are looking for someone who thrives in a dynamic work environment, and enjoys jumping into different challenges while still keeping the bigger picture in mind.

You bring not only technical skills, but also curiosity, creativity, and energy to the table. You are proactive and take initiative, you enjoy helping others, and value collaboration just as much as independence. You are hard-working, motivated, communicative, and adaptable, while keeping your eye on the scientific goals.

Your profile:

• A completed HLO or BSc/MSc degree in biomedical sciences, life sciences, or a related field.
• Proven experience in mammalian cell culture is a prerequisite.
• Hands-on experience with different molecular biology, cell-based techniques such as CRISPR-Cas9, western blot, PCR, electrophoresis, immunohistochemistry is an advantage.
• Self-motivated, structured work ethic with attention to detail and organizational skills.
• Effective communication skills in English.
• Results-oriented, flexible, and with a team-first mindset.

At Radboud university medical center, you build on your future. We are committed to providing the best care, education, and research. And we are true to our word, because we help you develop and seize opportunities and give you the room to grow. As an employer, we believe that employees should feel vital and happy at work in all stages of life. We are also committed to creating a healthy and safe working environment. Our employment conditions contribute to that. What we offer:

• A gross monthly salary between € 3.020 and € 4.041 (scale 7) for full-time employment (36 hours per week). You will also receive an 8% holiday allowance, an 8.3% end-of-year bonus, and, depending on the position, an allowance of 47% to 72% for working irregular hours.
• 176 vacation hours per year based on a 36-hour working week.

The Department of Human Genetics consists of three main sections: Clinical Genetics, Genome Research, and Genome Diagnostics. With respect to metabolic disorders, our theme focuses on a broad spectrum of inherited metabolic and neurological diseases, including glycosylation and mitochondrial disorders. In the area of scientific research, we collaborate closely with Genome Research and with the Departments of Pediatrics and Neurology.

Our Translational Metabolic Laboratory (TML) integrates patient care, research, and education, with an emphasis on developing new diagnostics through functional genomics, metabolomics, proteomics, and glycomics. We are committed to innovating the diagnostics of metabolic diseases through the application of these omics technologies. Our goal is to improve patient care and to maintain our strong international position in research and diagnostics.

Radboudumc
Welcome to Radboud university medical center (Radboudumc), where our research groups strive for innovative solutions that make impact on health and healthcare. We challenge the status quo to overcome current and future health challenges. Our goal is to shape the future of healthcare for generations to come. Our focus is on prevention, sustainability, and meaningful care, which we achieve through our in-depth understanding of disease mechanisms, clinical science, public health research, medical technology and data science. Our approach is centered on breakthroughs that can truly enhance personalized healthcare and public health.

At Radboudumc, a comprehensive range of research programs provide the compass for our research efforts. Each program has a clear goal, where collaboration within and outside our organization is highly valued. We integrate care, education and research in partnership with our patients to ensure that our research programs have significant impact on health and healthcare. We invite you to join us in our mission to create a healthy future for all.