Postdoc on the study to decipher the molecular mechanisms of Replication stress response

DNA replication represents a crucial, but potentially dangerous process that cells must complete to undergo cellular division. A failure to properly maintain the integrity of replicating chromosomes inevitably leads to genome instability, which is an early event in tumorigenesis. The candidate will be part of a diverse research team studying molecular and the structural mechanisms underlying DNA replication stress and how it could be exploited to drive chemosensitivity.

The main focus of the project will be to decipher the role of RNA processing in replication fork stability and how this process could be disrupted to achieve chemosensitivity in tumors. To study the molecular effects of RNA metabolism in replication stress response, the candidate will employ multiple state of the art technologies CRISPR/Cas9 genome editing, High content microscopy, modern sequencing and proteomics technologies and mouse transplantations in combination with structural technologies like Electron Microscopy.

A healthy population and excellence in healthcare through research and education. This is what Erasmus MC stands for. Conducting groundbreaking work, pushing boundaries and leading the way. In research, education, and healthcare. We are practical people with a high level of expertise, working hard to improve and renew the healthcare of today and the public health of tomorrow.

The candidate will be positioned at the Department of Molecular Genetics and will work in a research team focussed on the study various aspects of the DNA replication stress and its connection to the damage response to exploit this knowledge for improving anti-cancer therapy. The department of Molecular Genetics is a vibrant and international group of more than 50 researchers working on various aspects of DNA damage, DNA repair and other DNA damage responses.