PhD student Molecular Oncology

In this project, we study stem cell dynamics in early cancer development. Stem cells are essential for the homeostasis of most adult human tissues.

Previously we identified stem-like cells that fuel the growth and progression of colorectal cancers. We defined the impact of oncogenic mutations on stem cell dynamics in the intestine. We now use this knowledge and associated research tools to improve chemopreventive strategies and to develop novel, and more effective therapies for cancer.

We are seeking a dedicated and passionate PhD student to join our molecular oncology research team. This position offers a unique opportunity to contribute to cutting-edge research in cancer biology.

Responsibilities:

• Conduct research in molecular oncology, with a particular focus on heritable cancer syndromes.
• Design and perform experiments to investigate key molecular mechanisms underlying early cancer development.
• Utilize state-of-the-art disease models (in vitro models, organoid models, in vivo animal models) to study the effects of novel therapies or interventions.
• Analyze and interpret experimental data, and contribute to the publication of research findings.
• Collaborate with fellow researchers and participate in research meetings and discussions.
• Stay up-to-date with the latest advancements in the field and integrate new knowledge into ongoing research projects.

• A jump start to your career in research work.
• All te space for you to contribute shaping the care of tomorrow.
• Working on innovative research project togehter with motivated colleagues from all over the world.
• Salary scale OIO: € 2,789 to € 3,536 gross for full-time employment (depending on education and experience).
• In addition to a good basic salary, you will also receive 8.3% end-of-year bonus and 8% holiday allowance. Calculate your net salary here Bereken hier jouw netto salaris.
• Pension accrual with BeFrank, a modern, comprehensible and fairly priced pension.
• Excellent accessibility by public transport and reimbursement of a large part of your travel expenses. We also have sufficient parking spaces at the AMC location and a good bicycle scheme.

For an overview of all our other terms of employment, go to Employment conditions AMR - Amsterdam UMC

Arbeidsvoorwaarden AMR - Amsterdam UMC

Our lab seeks to elucidate the origin, the evolution and the heterogeneity of colorectal cancer. We develop and utilize state-of-the-art tools and techniques to study colorectal cancer heterogeneity and stem cell dynamics, including xenograft models, 3D organoids and gene editing technologies.

One key characteristic of our lab is the highly multidisciplinary composition, which allows us to approach scientific questions from many different perspectives. We value collegiality, enthusiasm, dedication, respect and reliability, thereby creating an optimal environment to successfully reach our goals. To learn more about the people and the research in our lab, please visit our website at www.vermeulenlab.org.